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NE-100 hydrochloride

Name: NE-100 hydrochloride
Brand: TargetMol
SKU: T20797
Price: 569 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.76%

货号 T20797Cas号 149409-57-4

别名 NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HCl

NE-100 hydrochloride (NE-100 HCl) 是选择性sigma-1 受体拮抗剂，IC50为 4.16 nM。它在体内具有抗精神病活性。它也能抑制内质网应激诱导的海马细胞死亡。

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NE-100 hydrochloride

一键复制产品信息

很棒

纯度: 99.76%

货号 T20797 别名 NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HClCas号 149409-57-4

NE-100 hydrochloride (NE-100 HCl) 是选择性sigma-1 受体拮抗剂，IC50为 4.16 nM。它在体内具有抗精神病活性。它也能抑制内质网应激诱导的海马细胞死亡。

规格	价格	库存
1 mg	¥ 569	现货
5 mg	¥ 1,180	现货
10 mg	¥ 1,680	现货
25 mg	¥ 2,930	现货
50 mg	¥ 4,260	现货
100 mg	¥ 5,920	现货
200 mg	¥ 8,130	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.76%

颜色: 白色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

NE-100 hydrochloride AI Summary

NE-100 hydrochloride exhibits high binding affinity for the Sigma opioid receptors, specifically Sigma receptor type 1 with an IC50 of 1.3 nM in both guinea pig and rat brain membranes. It also binds to the Sigma receptor type 2 with IC50 values of 1.5 nM and 212.0 nM, depending on the study. The compound demonstrates significantly lower affinity towards Dopamine receptor D2, 5-hydroxytryptamine 1A receptor, and Alpha-1 adrenergic receptor with IC50 values greater than 1000.0 nM, 6460.0 nM, and 10800.0 nM, respectively. Additionally, NE-100 hydrochloride shows no significant affinity for the serotonin transporter (SERT) and dopamine transporter (DAT). Pharmacologically, it reduces SKF-10047-induced stereotyped behavior in mice and inhibits methamphetamine-induced hyperlocomotion at an intraperitoneal dose of 10 mg/kg. Moreover, NE-100 hydrochloride displays antiviral activity against SARS-CoV-2 by inhibiting the virus’s cytotoxic effects on Caco-2 and VERO-6 cells at a 10 µM concentration after 48 hours, though the inhibition rates are somewhat limited. It also inhibits the SARS-CoV-2 3CL-Pro protease with 15.96% inhibition at a 20µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
靶点活性	σ1 receptor:4.16 nM
别名	NE-100 Hydrochloride, NE100 Hydrochloride, NE-100 HCl, NE 100 Hydrochloride, NE 100 HCl

化学信息

分子量	391.98
分子式	C₂₃H₃₄ClNO₂
CAS No.	149409-57-4
Smiles	Cl.CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (637.79 mM), Sonication is recommended.

H2O: 15 mg/mL (38.27 mM), Sonication and heating to 60℃ are recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5512 mL	12.7558 mL	25.5115 mL	127.5575 mL
5 mM	0.5102 mL	2.5512 mL	5.1023 mL	25.5115 mL
10 mM	0.2551 mL	1.2756 mL	2.5512 mL	12.7558 mL
20 mM	0.1276 mL	0.6378 mL	1.2756 mL	6.3779 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0510 mL	0.2551 mL	0.5102 mL	2.5512 mL
100 mM	0.0255 mL	0.1276 mL	0.2551 mL	1.2756 mL

计算器

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稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。