规格

价格

库存

数量

1 mg

¥ 455

现货

2 mg

¥ 661

现货

5 mg

¥ 993

现货

10 mg

¥ 1,630

现货

25 mg

¥ 2,760

现货

50 mg

¥ 3,970

现货

100 mg

¥ 5,860

现货

生物活性

产品描述	LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.
靶点活性	PP2A(Panc-1):3.87 μM, PP2A(BxPc-3):0.85 μM
体外活性	在胰腺癌异种移植小鼠模型中, LB-100（2 mg/kg,i.p.）可增加化疗药物阿霉素的疗效.LB-100使肿瘤表面血流速度和肿瘤微血管密度增加.
体内活性	与对照组相比,LB-100使细胞内阿霉素浓度升高约2.5倍,并增加肿瘤细胞对阿霉素的敏感性。LB-100使血管内皮生长因子分泌增加,从而促进HIF-1α-VEGF介导的血管生成。LB-100对BxPc-3（IC50：2.3 μM）和Panc-1（IC50：1.7 μM）细胞的生长有明显抑制效果。经LB-100处理后,BxPc-3、SW1990和Panc-1细胞肿的PP2A活性下降30-50%。
激酶实验	PP2A activity assays: Cultured pancreatic cancer cells are treated with IC50 of LB-100 for each cell line or equal volume of vehicle for 2 hours, and PP2A activity assays are then performed using Ser/Thr phosphatase assay kit. Cells are lysed with an ultrasonic cell disruptor, and the PP2A concentration is measured using a Ser/Thr phosphatase assay kit according to the instructions. Assays for each cell line are performed in triplicate.
细胞实验	Cytotoxicity is conducted by using a Cell Counting Kit-8. Cells are seeded in 96-well plates with a density of 3000 cells per well and are assessed after treatments following the CCK-8 protocol. Relative cytotoxicity is expressed as a percentage of speci?c controls. (Only for Reference)
别名	LB-100, LB 100

化学信息

分子量	268.31
分子式	C₁₃H₂₀N₂O₄
CAS No.	1632032-53-1
Smiles	C(=O)(C1[C@]2(O[C@@](C1C(O)=O)(CC2)[H])[H])N3CCN(C)CC3
密度	1.312 g/cm3 (Predicted)

储存&溶解度

存储

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 67.5 mg/mL (251.57 mM), Sonication is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	3.7270 mL	18.6352 mL	37.2703 mL	186.3516 mL
5 mM	0.7454 mL	3.7270 mL	7.4541 mL	37.2703 mL
10 mM	0.3727 mL	1.8635 mL	3.7270 mL	18.6352 mL
20 mM	0.1864 mL	0.9318 mL	1.8635 mL	9.3176 mL
50 mM	0.0745 mL	0.3727 mL	0.7454 mL	3.7270 mL
100 mM	0.0373 mL	0.1864 mL	0.3727 mL	1.8635 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

LB100

LB100

产品介绍

引用文献

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体内实验配液计算器

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关键词

LB100

LB100

LB100 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词