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顶部生物活性储存和溶解信息计算器

(R,S)-Anatabine (tartrate) (2743-90-0 free base)

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产品编号 T23228

别名 (R,S)-Anatabine (tartrate)

Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.

(R,S)-Anatabine (tartrate) (2743-90-0 free base)
其他形式的 “(R,S)-Anatabine (tartrate) (2743-90-0 free base)”:

(R,S)-Anatabine (tartrate) (2743-90-0 free base)

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产品编号 T23228 别名 (R,S)-Anatabine (tartrate)

Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.

规格价格库存数量
5 mg
¥ 952
2-4周
10 mg
¥ 1,683
2-4周
50 mg
¥ 7,353
2-4周
100 mg
¥ 12,834
2-4周
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产品介绍

生物活性
产品描述
Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tartrate) is preferable to (R,S)-Anatabine for certain applications and formulations.
体外活性

In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal-like SHSY-5Y cells. (R,S)-Anatabine also dose-dependently inhibits NF-κB activation [1].

体内活性

In vivo: In a transgenic mouse model with AD, treatment with anatabine for 4 days remarkably lowered brain soluble Aβ1-40 and Aβ1-42 levels [1].

别名(R,S)-Anatabine (tartrate)
化学信息
分子量310.3
分子式C10H12O2·C4H6O6
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 20 mg/mL (64.45 mM), Sonication is recommended.
Ethanol: ≤1 mg/mL
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.2227 mL16.1134 mL32.2269 mL161.1344 mL
5 mM0.6445 mL3.2227 mL6.4454 mL32.2269 mL
10 mM0.3223 mL1.6113 mL3.2227 mL16.1134 mL
20 mM0.1611 mL0.8057 mL1.6113 mL8.0567 mL
50 mM0.0645 mL0.3223 mL0.6445 mL3.2227 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments 一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

2743-90-0 free base(R,S)Anatabine (tartrate) (2743900 free base)Anatabine (tartrate)Anatabine2743-90-0(R,S) Anatabine (tartrate) (2743 90 0 free base)

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