Amikacin

Name: Amikacin
Brand: TargetMol
SKU: T1013
Price: 137 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.34%

货号 T1013Cas号 37517-28-5

别名 阿米卡霉素, Amikacinum, Amikacine, Amikacina

Amikacin (Amikacina) 是半合成的卡那霉素类似物，对革兰氏阴性菌 (包括庆大霉素和妥布霉素耐药菌株) 具有广谱活性，有耳毒性和肾毒性。

Amikacin

一键复制产品信息

很棒

纯度: 99.34%

货号 T1013 别名 阿米卡霉素, Amikacinum, Amikacine, AmikacinaCas号 37517-28-5

Amikacin (Amikacina) 是半合成的卡那霉素类似物，对革兰氏阴性菌 (包括庆大霉素和妥布霉素耐药菌株) 具有广谱活性，有耳毒性和肾毒性。

规格	价格	库存
5 mg	¥ 137	现货
10 mg	¥ 186	现货
25 mg	¥ 288	现货
50 mg	¥ 383	现货
100 mg	¥ 662	现货
200 mg	¥ 973	现货

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纯度: 99.34%

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产品介绍

Amikacin AI Summary

Amikacin exhibits a broad spectrum of antibacterial and antimycobacterial activities against various clinically significant bacterial strains. It shows potent activity against multiple strains of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, with minimum inhibitory concentration (MIC) values ranging from 0.5 to 256.0 µg/mL. The compound is effective against both methicillin-sensitive and methicillin-resistant Staphylococcus aureus, demonstrating lower MIC values against sensitive strains and higher values against resistant isolates. It also shows significant efficacy against Mycobacterium tuberculosis strains, including multidrug-resistant variants, with MIC values as low as 0.5 µg/mL. In addition to its antibacterial effects, Amikacin exhibits moderate to high potency against various Mycobacterium species such as Mycobacterium smegmatis, Mycobacterium bovis, and Mycobacterium avium, with MIC values indicating strong inhibitory effects. It also shows antimycobacterial activity with effective concentrations (such as IC50 and IC90) in the nanomolar range. Amikacin affects bacterial growth mechanisms, including binding dissociation constants, bacterial killing efficiencies, and inhibition of biofilm formation and FtsZ ring assembly. Additionally, it has shown a high selectivity ratio favoring bacterial translation inhibition over eukaryotic translation, highlighting its potential as an effective antibacterial agent with reduced cytotoxicity towards human cells. Overall, Amikacin demonstrates promising bioactivity for further exploration in antimicrobial research and drug development, particularly for its effectiveness against drug-resistant bacterial strains and its potential use in treating a variety of bacterial infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Amikacin (Amikacina) is a broad-spectrum antibiotic derived from kanamycin.
别名	阿米卡霉素, Amikacinum, Amikacine, Amikacina

化学信息

分子量	585.6
分子式	C₂₂H₄₃N₅O₁₃
CAS No.	37517-28-5
Smiles	NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O
密度	1.6 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 50 mg/mL (85.38 mM), Sonication is recommended.

DMSO: 45 mg/mL (76.84 mM), Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.7077 mL	8.5383 mL	17.0765 mL	85.3825 mL
5 mM	0.3415 mL	1.7077 mL	3.4153 mL	17.0765 mL
10 mM	0.1708 mL	0.8538 mL	1.7077 mL	8.5383 mL
20 mM	0.0854 mL	0.4269 mL	0.8538 mL	4.2691 mL
50 mM	0.0342 mL	0.1708 mL	0.3415 mL	1.7077 mL