Name: MF63
Brand: TargetMol
SKU: T16070
Price: 378 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 378

现货

5 mg

¥ 892

现货

10 mg

¥ 1,490

现货

25 mg

¥ 2,520

现货

50 mg

¥ 3,690

现货

100 mg

¥ 5,290

现货

200 mg

¥ 7,230

现货

1 mL x 10 mM (in DMSO)

¥ 981

现货

产品介绍

生物活性

产品描述

MF63 is a selective mPGES-1 inhibitor (IC50: 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively).

体外活性

MF63 strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme, in rodent species. mPGES-1 MF63 potently inhibited the human mPGES-1 enzyme with a high degree (>1000-fold) of selectivity over other prostanoid synthases. The compound selectively inhibited the synthesis of PGE(2) when tested in the guinea pig and a knock-in (KI) mouse expressing human mPGES-1, but not other prostaglandins inhibitable by nonsteroidal anti-inflammatory drugs (NSAIDs), yet retained NSAID-like efficacy at inhibiting lipopolysaccharide-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain.

化学信息

分子量	378.81
分子式	C₂₃H₁₁ClN₄
CAS No.	892549-43-8
Smiles	Clc1ccc2c3[nH]c(nc3c3ccccc3c2c1)-c1c(cccc1C#N)C#N
密度	1.49 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 43 mg/mL (113.51 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.28 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6398 mL	13.1992 mL	26.3985 mL	131.9923 mL
5 mM	0.5280 mL	2.6398 mL	5.2797 mL	26.3985 mL
10 mM	0.2640 mL	1.3199 mL	2.6398 mL	13.1992 mL
20 mM	0.1320 mL	0.6600 mL	1.3199 mL	6.5996 mL
50 mM	0.0528 mL	0.2640 mL	0.5280 mL	2.6398 mL
100 mM	0.0264 mL	0.1320 mL	0.2640 mL	1.3199 mL

体内实验配液计算器