PEPA

Name: PEPA
Brand: TargetMol
SKU: T12406
Price: 121 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 97.31%

货号 T12406Cas号 141286-78-4

PEPA 是一种变构 AMPA 受体调节剂，可与 GluA2o 和 GluA3o LBD 结合，可用作 AMPA 受体异质性的指标。

PEPA

一键复制产品信息

很棒

纯度: 97.31%

货号 T12406Cas号 141286-78-4

PEPA 是一种变构 AMPA 受体调节剂，可与 GluA2o 和 GluA3o LBD 结合，可用作 AMPA 受体异质性的指标。

规格	价格	库存
1 mg	¥ 121	现货
5 mg	¥ 275	现货
10 mg	¥ 418	现货
25 mg	¥ 697	现货
50 mg	¥ 1,030	现货
1 mL x 10 mM (in DMSO)	¥ 313	现货

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COA LCMS HNMR 产品操作手册

产品介绍

PEPA AI Summary

PEPA exhibits a diverse range of bioactivities. It functions as a potentiator of glutamate-induced currents in various glutamate receptor isoforms, including GluA1, GluA2, GluA3, and GluA4, as well as their specific flip and flop isoforms, suggesting its role in modulating glutamate receptors critical for synaptic transmission in the central nervous system. Additionally, PEPA shows potency as an agonist for the NFkB signaling pathway and acts as both an inhibitor and antagonist in other pathways, such as the Hypoxia Response Element Signaling Pathway and the Aldehyde Dehydrogenase 1 pathway. It also inhibits several enzymes and proteins, including HADH2, Nrf2, Histone Lysine Methyltransferase G9a, T. brucei phosphofructokinase, Mammalian Selenoprotein Thioredoxin Reductase 1, and impacts Lassa Virus binding or entry into cells, as well as ATXN expression. Furthermore, it is active in cytochrome panel assays, affecting p450-cyp3a4 and p450-cyp1a2 pathways, highlighting its extensive bioactivity across various biological targets and pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

化学信息

分子量	402.44
分子式	C₁₆H₁₆F₂N₂O₄S₂
CAS No.	141286-78-4
Smiles	NC(=O)COc1c(F)cc(SCCNS(=O)(=O)c2ccccc2)cc1F
密度	1.47 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (124.24 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.97 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4848 mL	12.4242 mL	24.8484 mL	124.2421 mL
5 mM	0.4970 mL	2.4848 mL	4.9697 mL	24.8484 mL
10 mM	0.2485 mL	1.2424 mL	2.4848 mL	12.4242 mL
20 mM	0.1242 mL	0.6212 mL	1.2424 mL	6.2121 mL
50 mM	0.0497 mL	0.2485 mL	0.4970 mL	2.4848 mL
100 mM	0.0248 mL	0.1242 mL	0.2485 mL	1.2424 mL