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Ondansetron

Name: Ondansetron
Brand: TargetMol
SKU: T6615
Price: 255 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.92%

货号 T6615Cas号 99614-02-5

别名 恩丹西酮, 昂丹司琼, SN 307, GR-C507/75, GR 38032F, GR 38032

Ondansetron (GR 38032) 是一种血清素 5-HT3 受体拮抗剂，主要用作止吐剂。

Ondansetron

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很棒

纯度: 99.92%

货号 T6615 别名 恩丹西酮, 昂丹司琼, SN 307, GR-C507/75, GR 38032F, GR 38032Cas号 99614-02-5

Ondansetron (GR 38032) 是一种血清素 5-HT3 受体拮抗剂，主要用作止吐剂。

规格	价格	库存
5 mg	¥ 255	现货
10 mg	¥ 418	现货
25 mg	¥ 515	现货
50 mg	¥ 671	现货
100 mg	¥ 840	现货
1 mL x 10 mM (in DMSO)	¥ 460	现货

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实验操作小课堂

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纯度: 99.92%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Ondansetron AI Summary

Ondansetron exhibits a variety of bioactivities primarily related to its high affinity for the 5-hydroxytryptamine 3 (5-HT3) receptor. It demonstrates potent antagonist activity against this receptor, with Ki values as low as 0.77 nM and IC50 values in the range of 1.4 to 1.95 nM in different assays. This compound effectively inhibits 5-HT3 receptor-induced responses, such as bradycardia and emesis, with significant efficacy in both in vitro and in vivo models. For instance, it exhibits an ID50 of 0.0036 mg/kg for inhibiting 5-HT-evoked reflex bradycardia in rats, and an ED50 of 0.008 mg/kg intravenously for reducing cisplatin-induced emetic episodes in ferrets and dogs. Additionally, Ondansetron has shown various degrees of inhibitory activity against other receptors and enzymes. It displays weak binding affinities for receptors such as dopamine D2, 5-HT1, and 5-HT2, with Ki values greater than 1000 nM. The compound also shows moderate effectiveness in inhibiting human liver transporters (e.g., OCT1, HERG, BSEP) and enzymes, with IC50 values ranging from 400 nM to greater than 135,000 nM. Furthermore, in pharmacokinetic evaluations, Ondansetron has an oral bioavailability of 79%, a volume of distribution at steady state (Vdss) of 1.8 L/kg, and demonstrates a hepatic clearance rate of 5.8 mL/min/kg. It also exhibits an unbound fraction of 0.27 in human plasma and a half-life (T1/2) of 3.4 hours after intravenous administration in humans. In terms of therapeutic relevance, Ondansetron has exhibited antiemetic properties and antidepressant-like activities in animal models, as well as minimal hepatotoxic effects. However, it has limited efficacy against specific viruses, including SARS-CoV-2, with antiviral assay results indicating low effectiveness. Overall, Ondansetron’s primary pharmacological action is as a potent antagonist of the 5-HT3 receptor, making it a potential candidate for treating conditions such as chemotherapy-induced nausea and vomiting, with additional relevance in various serotonin-related physiological functions..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ondansetron (GR 38032) is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
靶点活性	5-HT:103 pM
别名	恩丹西酮, 昂丹司琼, SN 307, GR-C507/75, GR 38032F, GR 38032

化学信息

分子量	293.36
分子式	C₁₈H₁₉N₃O
CAS No.	99614-02-5
Smiles	Cl.CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2
密度	1.27 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 4 mg/mL (13.64 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.41 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4088 mL	17.0439 mL	34.0878 mL	170.4391 mL
5 mM	0.6818 mL	3.4088 mL	6.8176 mL	34.0878 mL
10 mM	0.3409 mL	1.7044 mL	3.4088 mL	17.0439 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

SN-307 SN307 Serotonin Receptor Ondansetron Inhibitor inhibit GR-38032 GR38032 5-hydroxytryptamine Receptor 5HTReceptor 5-HT3 5-HT Receptor 5HT Receptor 5-HT

Ondansetron

Ondansetron

Ondansetron 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

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