Ibandronic acid

Name: Ibandronic acid
Brand: TargetMol
SKU: T1599
Price: 173 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

货号 T1599Cas号 114084-78-5

别名 伊班膦酸, Bonviva, Boniva, Bondronat

Ibandronic acid (Bonviva) 是一种高效含氮双磷酸盐，可作用于骨质疏松，具有抗吸收和抗高钙血症作用。

Ibandronic acid

一键复制产品信息

很棒

货号 T1599 别名 伊班膦酸, Bonviva, Boniva, BondronatCas号 114084-78-5

Ibandronic acid (Bonviva) 是一种高效含氮双磷酸盐，可作用于骨质疏松，具有抗吸收和抗高钙血症作用。

规格	价格	库存
10 mg	¥ 173	现货
25 mg	¥ 245	现货
50 mg	¥ 325	现货
100 mg	¥ 432	现货

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产品介绍

Ibandronic acid AI Summary

Ibandronic acid exhibits diverse bioactivities and has shown significant potency in various assays. It demonstrates in vitro growth inhibition of Trypanosoma brucei rhodesiense bloodstream forms with an IC50 value of 960.0 nM and a predicted pIC50 value close to this. The compound also effectively inhibits the human recombinant farnesyl pyrophosphate synthase (FPPSase) and geranylgeranyl diphosphate synthase (GGPPSase) with IC50 values of 20.0 nM and approximately 79432.82 nM, respectively. Additionally, it reduces hypercalcemia in TPTX rats at an ED50 of 0.0011 mg/kg and exhibits bone resorption inhibition activity in rats at a minimum effective dose of 0.0001 mg/kg. In the context of immunomodulation, Ibandronic acid inhibits TNF-alpha release in gamma-delta T cells with IC50 values ranging around 31,000 nM and activates these cells at an EC50 concentration of 1000.0 nM. It also inhibits osteoclast formation in RAW264.7 cells, diminishing their count under specified conditions. Despite its broad spectrum of actions, the compound shows no significant antibacterial activity against Escherichia coli W3110. However, it inhibits the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells with an IC50 of 54920.0 nM and shows selectivity towards the parasite with a LD50 of 10.4 μM for KB cells. Pharmacokinetically, Ibandronic acid exhibits a fraction unbound of 0.15 in humans, a volume of distribution at steady state of 0.55 L/kg, and a clearance of 1.8 mL/min/kg, with a half-life of 14.0 hours following intravenous administration. While studies indicate moderate liver toxicity with elevated liver enzyme levels, there is no significant evidence of severe hepatic side effects or liver disease. Moreover, it inhibits HDAC6 enzyme activity and human ACMSD, reducing Quinolinic acid levels substantially. Overall, Ibandronic acid interacts with a wide variety of receptors, functioning as both an agonist and antagonist, suggesting extensive pharmacological potential in targeting multiple biological processes and therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Ibandronic acid (Bonviva) is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities.
别名	伊班膦酸, Bonviva, Boniva, Bondronat

化学信息

分子量	319.23
分子式	C₉H₂₃NO₇P₂
CAS No.	114084-78-5
Smiles	CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O
密度	1.449 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 50 mg/mL (156.63 mM), Sonication is recommended.

DMSO: Slightly soluble

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	3.1325 mL	15.6627 mL	31.3254 mL	156.6269 mL
5 mM	0.6265 mL	3.1325 mL	6.2651 mL	31.3254 mL
10 mM	0.3133 mL	1.5663 mL	3.1325 mL	15.6627 mL
20 mM	0.1566 mL	0.7831 mL	1.5663 mL	7.8313 mL
50 mM	0.0627 mL	0.3133 mL	0.6265 mL	3.1325 mL
100 mM	0.0313 mL	0.1566 mL	0.3133 mL	1.5663 mL