Nicergoline

Name: Nicergoline
Brand: TargetMol
SKU: T1132
Price: 255 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.80%

货号 T1132Cas号 27848-84-6

别名 尼麦角林, Nimergoline, Nicergolinum

Nicergoline (Nicergolinum) 是一种有效的，选择性的、具有口服活性的α1A-肾上腺素能受体拮抗剂，是一种溴烟碱酸的麦角林衍生物。它具有血管舒张作用，可以改善阿尔茨海默症小鼠的认知功能。

Nicergoline

一键复制产品信息

很棒

纯度: 99.80%

货号 T1132 别名 尼麦角林, Nimergoline, NicergolinumCas号 27848-84-6

规格	价格	库存
5 mg	¥ 255	现货
10 mg	¥ 413	现货
25 mg	¥ 515	现货
50 mg	¥ 663	现货
100 mg	¥ 1,010	现货
200 mg	¥ 1,530	现货
500 mg	¥ 2,660	现货
1 mL x 10 mM (in DMSO)	¥ 315	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.80%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Nicergoline AI Summary

Nicergoline exhibits a diverse range of bioactivities across multiple biological pathways and interactions. This includes notable inhibition of Menin-MLL interaction in MLL-related leukemias, Human Jumonji Domain Containing 2E (JMJD2E), Tyrosyl-DNA Phosphodiesterase (TDP1), Tau fibril formation, and the interaction between CBF-beta and RUNX1 for Acute Myeloid Leukemia treatment. Additionally, it demonstrates effects on lipid storage modulation and vitamin D receptor (VDR) inhibition, along with blocking malaria parasite plastid. The compound also shows potential in blocking the entry of the Ebola virus. In CHO cells transfected with OATP1B3 and OATP1B1, Nicergoline inhibits sodium fluorescein uptake significantly, with inhibition percentages of 124.07% and 91.22% at 10 µM, respectively. However, in assays related to SARS-CoV-2, the results are mixed. It shows limited inhibition of cell viability in Vero E6 cells (inhibition index of -0.08213), some antiviral activity in Caco-2 cells with -11.94% inhibition, and a modest hit score of 0.1321 in HRCE cells. It also exhibits 20.38% inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM and no inhibition of cytotoxicity in VERO-6 cells. Furthermore, Nicergoline inhibits human HDAC6 activity but with varying results dependent upon the peptide substrate used: -49.11% inhibition with a commercial substrate versus -0.19% with a custom one. It also exhibits selective binding to receptors like DRD1, KCNH2, and SLC6A3, and shows antagonist activity at TBXA2R while acting as an agonist at ADORA3 and HTR2B. This compound is evaluated for inhibiting enzymes such as ACHE, MAOA, and PTGS1, displaying a broad spectrum of bioactivities affecting numerous receptors and enzymes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.
别名	尼麦角林, Nimergoline, Nicergolinum

化学信息

分子量	484.39
分子式	C₂₄H₂₆BrN₃O₃
CAS No.	27848-84-6
Smiles	O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3
密度	1.47 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (103.22 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.13 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0645 mL	10.3223 mL	20.6445 mL	103.2226 mL
5 mM	0.4129 mL	2.0645 mL	4.1289 mL	20.6445 mL
10 mM	0.2064 mL	1.0322 mL	2.0645 mL	10.3223 mL
20 mM	0.1032 mL	0.5161 mL	1.0322 mL	5.1611 mL
50 mM	0.0413 mL	0.2064 mL	0.4129 mL	2.0645 mL
100 mM	0.0206 mL	0.1032 mL	0.2064 mL	1.0322 mL