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Ginsenoside Rd
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很棒纯度: 99.92%
货号 T2878Cas号 52705-93-8
别名 人参皂苷Rd, 人参皂苷 Rd, Sanchinoside Rd, Panaxoside Rd, Gypenoside VIII
Ginsenoside Rd (Gypenoside VIII) 抑制 TNFα 诱导的NF-κB 转录活性，还抑制COX-2和iNOSmRNA 的表达。它抑制CYP2D6、CYP1A2、CYP3A4和CYP2C9，也抑制Ca2+内流，有可能抑制或阻止肿瘤生长。
其他形式的 “Ginsenoside Rd”:
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Ginsenoside Rd
一键复制产品信息 很棒纯度: 99.92%
货号 T2878 别名 人参皂苷Rd, 人参皂苷 Rd, Sanchinoside Rd, Panaxoside Rd, Gypenoside VIIICas号 52705-93-8
Ginsenoside Rd (Gypenoside VIII) 抑制 TNFα 诱导的NF-κB 转录活性，还抑制COX-2和iNOSmRNA 的表达。它抑制CYP2D6、CYP1A2、CYP3A4和CYP2C9，也抑制Ca2+内流，有可能抑制或阻止肿瘤生长。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 257 | 现货 | |
| 5 mg | ¥ 578 | 现货 | |
| 10 mg | ¥ 996 | 现货 | |
| 25 mg | ¥ 1,660 | 现货 | |
| 50 mg | ¥ 2,480 | 现货 | |
| 100 mg | ¥ 3,670 | 现货 | |
| 500 mg | ¥ 7,920 | 5日内发货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 987 | 现货 |
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产品介绍
Ginsenoside Rd AI Summary
Ginsenoside Rd shows hepatoprotective activity in mouse hepatocytes, effectively inhibiting D-galactosamine/TNFalpha-induced cell death at concentrations of 50 uM, 100 uM, and 200 uM, with inhibition percentages ranging from 17.5% to 39.1%. It also provides protective activity against the same stimuli, with percentages between 7.4% and 16.8%. Furthermore, it demonstrates significant hepatoprotective effects in ddY mice against D-galactosamine/LPS-induced liver injury, reducing serum alanine transaminase and aspartate transaminase levels by 97.0% and 93.0%, respectively, at a dose of 100 mg/kg.
In addition, Ginsenoside Rd does not significantly inhibit human DNA topoisomerase 1 or 2, showing IC50 values greater than 250,000 nM. It inhibits superoxide anion generation in human neutrophils stimulated by fMLP/CB slightly at 30 uM, as evidenced by a -3.54% inhibition. It also modestly inhibits human neutrophil degranulation with a 2.88% inhibition of elastase release at the same concentration.
The compound inhibits cell proliferation in human U251 cells and rat C6 cells, with inhibition rates of 78.36% and 102.07%, respectively, after 72 hours, as measured by the sulforhodamine B assay. Additionally, it activates AMPKalpha2beta1gamma1 in the presence of CaMKKbeta with an EC50 value of 16.8 nM.
Antiviral properties of Ginsenoside Rd include the inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 uM, with inhibition rates of -4.52% and -0.06%, respectively, after 48 hours. Moreover, it inhibits SARS-CoV-2 3CL-Pro protease by 7.699% at 20 µM. Lastly, the compound exhibits weak HDAC6 inhibitory activity, with inhibition percentages of 6.33% using commercial substrates and 0.27% with custom peptide substrates..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. |
| 靶点活性 | CYP3A4:81.7±2.6 μM, NF-κB:12.05 μM (in HepG2 cells), CYP1A2:78.4±5.3 μM, CYP2D6:58.0±4.5 μM, CYP2C9:85.1±9.1 μM |
| 别名 | 人参皂苷Rd, 人参皂苷 Rd, Sanchinoside Rd, Panaxoside Rd, Gypenoside VIII |
| 分子量 | 947.15 |
| 分子式 | C48H82O18 |
| CAS No. | 52705-93-8 |
| Smiles | [H][C@@]12[C@H](CC[C@@]1(C)[C@]1(C)CC[C@@]3([H])C(C)(C)[C@H](CC[C@]3(C)[C@@]1([H])C[C@H]2O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)(CCC=C(C)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |
| 密度 | 1.37 g/cm3 |
| 存储 | keep away from direct sunlight,keep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 50 mg/mL (52.79 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.11 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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TCMIP相关数据
中药材来源及性味归经
所属中成药
| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 三七花 | Panax notoginseng (Burk.) F.H.Chen | 凉 | 甘 | 肝, 肾 |
| 中成药名称 | 处方组成 | 中成药类型 |
|---|---|---|
| 田七花叶颗粒 | 三七叶茎,三七花 | 清热药 |
| 田七花叶颗粒（田七花精） | 三七叶茎,三七花 | 清热药 |
| 三七花冲剂 | 三七花 | 祛风药 |
| 三七花颗粒 | 三七花 | 清热药 |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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