购物车

您的购物车当前为空

Quetiapine

Name: Quetiapine
Brand: TargetMol
SKU: T0162
Price: 281 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.96%

货号 T0162Cas号 111974-69-7

别名 喹硫平, Quetiapin, ICI204636

Quetiapine (ICI204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂，对人5-HT1A 的 pEC50值为 4.77，对人 D2的 pIC50值为 6.33。它用于治疗精神分裂症，以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人 D2、HT1、5-HT2A、5-HT2C 受体具有中高等亲和力，pKi 值为 7.25、5.74、7.54和5.55。

Quetiapine

一键复制产品信息

很棒

纯度: 99.96%

货号 T0162 别名 喹硫平, Quetiapin, ICI204636Cas号 111974-69-7

规格	价格	库存
5 mg	¥ 281	现货
10 mg	¥ 460	现货
25 mg	¥ 679	现货
50 mg	¥ 832	现货
100 mg	¥ 990	现货
1 mL x 10 mM (in DMSO)	¥ 349	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.96%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Quetiapine AI Summary

Quetiapine exhibits a broad spectrum of bioactivities primarily through interactions with various neurotransmitter receptors. It shows high affinity for dopamine receptors D1, D2, D3, and D4, with particularly strong binding to the D2 receptor (Ki = 63.1 nM). Additionally, it binds to several serotonin receptors, including 5-HT1A (Ki = 79.43 nM) and 5-HT2A (Ki = 63.1 nM), indicating significant neuromodulatory potential. The compound also demonstrates noteworthy binding to histamine H1 (Ki = 39.81 nM) and adrenergic alpha-1 (Ki = 12.59 nM) receptors, showing potential implications in both the dopaminergic and serotonergic systems. In vivo efficacy is shown in animal models where Quetiapine antagonizes apomorphine-induced climbing and stereotypy behaviors in mice (ED50 values of 51.0 and 60.0 μmol/kg, respectively), as well as reducing dyskinesias in haloperidol-sensitized cebus monkeys in a dose-dependent manner. The compound also affects various physiological processes, impacting liver and kidney functions, bioavailability via BBB penetration (Kp = 8.5), and shows moderate binding to the human estrogen receptor. Moreover, Quetiapine has been involved in various functional assays demonstrating: H1 receptor antagonism (IC50 = 40.0 nM), serotonin receptor antagonism in the 5-HT2A receptor (IC50 = 31.0 nM), and has properties suggesting low hepatotoxicity as per the Drug Induced Liver Injury Prediction System. Its pharmacokinetic profile includes low excretion, a terminal half-life of approximately 6 hours in humans, and strong brain-binding affinity which may point towards its potential central nervous system effects. Antiviral activities are noted against SARS-CoV-2, with moderate potency (IC50 > 19952.62 nM). Additionally, the compound shows modest antiproliferative activity against human PC3 cells and exhibits other bioactivities, such as inhibition of the L-type calcium channel and human HDAC6 enzyme. These diverse interactions make Quetiapine a compound of interest for further pharmacological research and development..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.
靶点活性	5-HT1A receptor:5.74 (pKi), 5-HT2A receptor:7.54 (pKi), D2 Receptor:6.33 (pIC50), D2 Receptor:7.25 (pKi), 5-HT2C receptor:5.55 (pKi), 5-HT1A receptor:4.77 (pEC50)
别名	喹硫平, Quetiapin, ICI204636

化学信息

分子量	383.51
分子式	C₂₁H₂₅N₃O₂S
CAS No.	111974-69-7
Smiles	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
密度	1.27 g/cm3
颜色	Transparent
物理性状	Solid

储存&溶解度

存储

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 120 mg/mL (312.9 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.21 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6075 mL	13.0375 mL	26.0749 mL	130.3747 mL
5 mM	0.5215 mL	2.6075 mL	5.2150 mL	26.0749 mL
10 mM	0.2607 mL	1.3037 mL	2.6075 mL	13.0375 mL
20 mM	0.1304 mL	0.6519 mL	1.3037 mL	6.5187 mL
50 mM	0.0521 mL	0.2607 mL	0.5215 mL	2.6075 mL
100 mM	0.0261 mL	0.1304 mL	0.2607 mL	1.3037 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

Quetiapine

Quetiapine

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Quetiapine

Quetiapine

Quetiapine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词