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Beclamide

Name: Beclamide
Brand: TargetMol
SKU: T1249
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.58%

货号 T1249Cas号 501-68-8

别名 贝克拉胺(INN), 贝克拉胺, N-Benzyl-3-chloropropionamide, Chlorakon, Chloracon

Beclamide (Chlorakon) 是一种抗惊厥药，具有抗惊厥作用。

Beclamide

一键复制产品信息

很棒

纯度: 98.58%

货号 T1249 别名 贝克拉胺(INN), 贝克拉胺, N-Benzyl-3-chloropropionamide, Chlorakon, ChloraconCas号 501-68-8

Beclamide (Chlorakon) 是一种抗惊厥药，具有抗惊厥作用。

规格	价格	库存
50 mg	¥ 126	现货
100 mg	¥ 208	现货
200 mg	¥ 276	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 98%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Beclamide AI Summary

Beclamide exhibits a range of pharmacological activities, including anticonvulsant, antiviral, and enzymatic inhibitory effects. It has shown efficacy as an anticonvulsant with an effective dose (ED50) of 117.0 mg/kg in the metrazole-induced convulsion test and 185.0 mg/kg in the maximal electroshock induced convulsion test, both administered subcutaneously. The compound's toxicity (TD50) was determined to be 278.0 mg/kg in the rotarod toxicity test. In antiviral studies, Beclamide has demonstrated inhibitory effects against various viruses. It inhibits Ebola Virus entry with AC50 values ranging from 5.623 µM to 11,220.2 nM according to PubChem BioAssays. Regarding SARS-CoV-2, the compound inhibits virus-induced cytotoxicity in VERO-6 and Caco-2 cells, although with varying degrees of efficacy. The inhibition index was 0.4238 in Vero E6 cells at a 0.002 MOI after 72 hours, and the inhibition rate was 6.11% in Caco-2 cells at 10 µM concentration after 48 hours. However, it exhibited lower activity in HRCE cells with a hit score of 0.1071 and a 9.71% inhibition of SARS-CoV-2 3CL-Pro protease at a concentration of 20µM. The IC50 value against SARS-CoV-2 was reported to be higher than 20,000.0 nM after 48 hours of exposure. Furthermore, Beclamide shows inhibitory activity against human HDAC6, as evidenced by a decrease in enzymatic activity in assays utilizing both commercial and custom peptide substrates..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Beclamide (Chlorakon) (N-benzyl-B-chloropropionamide) is a drug that possesses anticonvulsant activity. It is no longer used. It has been used as a sedative and as an anticonvulsant. It was studied in the 1950s for its anticonvulsant properties, as a treatment for generalized tonic-clonic seizures. It was not effective for absence seizures.
别名	贝克拉胺(INN), 贝克拉胺, N-Benzyl-3-chloropropionamide, Chlorakon, Chloracon

化学信息

分子量	197.66
分子式	C₁₀H₁₂ClNO
CAS No.	501-68-8
Smiles	ClCCC(=O)NCc1ccccc1
密度	1.145g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (252.96 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.12 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0592 mL	25.2960 mL	50.5919 mL	252.9596 mL
5 mM	1.0118 mL	5.0592 mL	10.1184 mL	50.5919 mL
10 mM	0.5059 mL	2.5296 mL	5.0592 mL	25.2960 mL
20 mM	0.2530 mL	1.2648 mL	2.5296 mL	12.6480 mL
50 mM	0.1012 mL	0.5059 mL	1.0118 mL	5.0592 mL
100 mM	0.0506 mL	0.2530 mL	0.5059 mL	2.5296 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Inhibitor inhibit Beclamide

Beclamide

Beclamide

Beclamide 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词