表皮生长因子家族 (Epidermal Growth Factor Family, EGFs)

EGF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 6.35 kDa and the accession number is P01133-1.

Betacellulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36 kDa and the accession number is P35070.

The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor that might contribute to the development of Cleft lip and palate (CL P).

Expression system: HEK293 Cells
Length: 56-101, Full Length of Mature Protein
Activity: Cell Activity

EGF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 33 kDa and the accession number is P01133-1.

Expression system: E. coli
Length: 2-62, Partial
Activity: Not Tested

Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL P) and of nonsyndromic cleft palate only (NS-CPO). Biologic support for a role of TGFA arises from its presence at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice. TGF alpha Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 32.9 kDa and the accession number is P48030.

Neuregulin-1 NRG1 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34 kDa and the accession number is XP_858147.1.

EGF Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 6.3 kDa and the accession number is P07522.

Expression system: HEK293 Cells
Length: 977-1029, Partial
Activity: Organoid Coculture、Cells

Expression system: P. pastoris (Yeast)
Length: 977-1029, Partial
Activity: Cell Activity

Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.

NRG1 beta 1 Protein, Human, Recombinant (aa 176-246) is expressed in E. coli. The accession number is Q02297-6.

Neuregulin-1 NRG1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.5 kDa and the accession number is Q02297-12.

NRG1 beta 1 Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 36.7 kDa and the accession number is Q02297-6.

EGF Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is P01133.

NRG1 beta 1 Protein, Human, Recombinant (CHO) is expressed in CHO Cells. The accession number is Q02297-6.

Neuregulin-1 NRG1 Protein, Canine, Recombinant (aa 19-240, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.5 kDa and the accession number is XP_858147.1.

Neuregulin-1 NRG1 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 24.7 kDa and the accession number is XP_858147.1.

Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction.

Expression system: E. coli
Length: 32-111, Partial
Activity: Cell Activity

Expression system: Baculovirus Insect Cells
Length: 24-273, Full Length of Mature Protein
Activity: Cell Activity

Expression system: E. coli
Length: 60-108, Partial
Activity: Cell Activity