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Adrenosterone

Name: Adrenosterone
Brand: TargetMol
SKU: T2207
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.29%

货号 T2207Cas号 382-45-6

别名 肾上腺甾酮, Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedione

Adrenosterone (11-ketoandrostenedione) 是一种人内源性代谢物，由肾上腺皮质产生。Adrenosterone 是一种竞争性羟基类固醇脱氢酶 1 抑制剂。它是一种的类固醇激素，具有较弱的雄激素特性。它是一种膳食补充剂，能够减少脂肪并提高肌肉质量。它能够抑制人类癌细胞的转移进展。

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Adrenosterone

一键复制产品信息

很棒

纯度: 98.29%

货号 T2207 别名 肾上腺甾酮, Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedioneCas号 382-45-6

规格	价格	库存
25 mg	¥ 132	现货
50 mg	¥ 178	现货
100 mg	¥ 247	现货
500 mg	¥ 496	现货
1 g	¥ 745	现货
2 g	¥ 953	现货
1 mL x 10 mM (in DMSO)	¥ 260	现货

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大包装 & 定制

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该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

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选择批次:

纯度: 98.29%

颜色: 白色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Adrenosterone AI Summary

Adrenosterone displays a range of bioactivities across different biological systems. In rats, it shows anabolic and androgenic activity, increasing the levator ani muscle weight and enlarging the ventral prostate and seminal vesicle, respectively, with an anabolic to androgenic activity ratio of 1.1. The compound has a lipophilicity value (LogP) of 3.75. In various biochemical assays, Adrenosterone enhances the expression of the SMN2 splice variant (potency: 1258.9 nM), inhibits AmpC Beta-Lactamase (potency: 22387.2 nM), DNA Polymerase Beta (potency: 4466.8 nM), alpha-syn (potency: 5623.4 nM), GLP-1 receptor (inverse agonist, potency: 12589.3 nM), USP1/UAF1 (potency: 89125.1 nM), and MBNL1-poly(CUG) RNA binding (potency: 891.3 nM). It also affects HP1-beta Chromodomain interactions with methylated histone tails (potency: 100000.0 nM) and induces DNA re-replication in MCF 10a normal breast cells (potency: 5173.5 nM). Regarding its antiviral activity, Adrenosterone demonstrates inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, although with relatively low potency (inhibition rates of 0.15% and 0.05% respectively). It also exhibits SARS-CoV-2 3CL-Pro protease inhibition activity at 20µM, with an inhibition percentage of 10.66%. The compound has a permeability value (Peff) of 6.05 x 10^-6 cm/s in the PAMPA-BBB penetration assay, indicating its potential to cross the blood-brain barrier. Inhibition of human HDAC6 enzymatic activity by Adrenosterone is mixed, with a slight decrease (-8.56%) in activity with a commercial peptide substrate and a minor increase (1.32%) using a custom peptide substrate, suggesting moderate bioactivity on human HDAC6..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
别名	肾上腺甾酮, Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedione

化学信息

分子量	300.39
分子式	C₁₉H₂₄O₃
CAS No.	382-45-6
Smiles	CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C1CCC2=O
密度	1.18g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (83.23 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.33 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3290 mL	16.6450 mL	33.2901 mL	166.4503 mL
5 mM	0.6658 mL	3.3290 mL	6.6580 mL	33.2901 mL
10 mM	0.3329 mL	1.6645 mL	3.3290 mL	16.6450 mL
20 mM	0.1665 mL	0.8323 mL	1.6645 mL	8.3225 mL
50 mM	0.0666 mL	0.3329 mL	0.6658 mL	3.3290 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。