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5a-Pregnane-3,20-dione 是内源性的孕酮代谢物。
5a-Pregnane-3,20-dione 是内源性的孕酮代谢物。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | ¥ 163 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 150 | 现货 |
产品描述 | 5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone |
体外活性 | 内源性孕酮代谢产物5α-Pregnane-3,20-dione可能通过影响粘附分子和细胞骨架分子,促进乳腺肿瘤和转移的发生。 |
细胞实验 | MCF-7 cells were grown without or with 5a-Pregnane-3,20-dione (10(-9)-10(-5) M), and the effects on cell and nuclear morphology, adhesion plaques, vinculin and actin expression, actin polymerization, and microfilament distribution were examined by immunohistochemistry, morphometry (using confocal microscopy and digital computer imaging analysis), and Western blotting.?Treatment of cells with 10(-9)-10(-6) M 5a-Pregnane-3,20-dione resulted in dose-dependent decreases in cell area, cell-to-cell contacts, and attachment to the substratum, and increases in variation in nuclear area.?These changes in the 5alphaP-treated cells were accompanied by decreases in vinculin-containing adhesion plaques, vinculin expression, polymerized actin stress fibers, and decreases in insoluble and increases in soluble actin fractions. |
别名 | 氢化黄体酮 |
分子量 | 316.48 |
分子式 | C21H32O2 |
CAS No. | 566-65-4 |
Smiles | [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C |
密度 | 1.048 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 5 mg/mL (15.80 mM), Sonication and heating are recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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