规格

价格

库存

数量

1 mg

¥ 438

现货

5 mg

¥ 1,060

现货

10 mg

¥ 1,780

现货

25 mg

¥ 3,580

现货

50 mg

¥ 5,130

现货

100 mg

¥ 6,930

现货

200 mg

¥ 9,530

现货

1 mL x 10 mM (in DMSO)

¥ 1,160

现货

生物活性

产品描述	MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).
靶点活性	MTAP:90 pM (Ki, cell free)
体外活性	在培养细胞中使用MTA和MT-DADMe-ImmA可抑制MTAP活性，增加细胞内MTA浓度，降低多胺水平，并在两种头颈部鳞状细胞癌细胞系FaDu和Cal27中诱导凋亡。单独使用MT-DADMe-ImmA并不在任何细胞系中诱发凋亡[2]。
体内活性	MTAP 活性逐渐恢复，口服 MT-DADMe-ImmA 的生物半衰期为 6.3 天。在免疫缺陷鼠中，FaDu 肿瘤的时间依赖性增长通过口服或腹腔内使用 MT-DADMe-ImmA [2] 被抑制。
细胞实验	Cell viability is evaluated using the Alamar Blue assay. Cells are seeded onto 96-well plates at a density of 10^4 cells/well and incubated with increasing concentrations of MT-DADMe-ImmA (100 pM to 100 μM) for 4 days at fixed MTA concentrations (0, 5, 10, and 20 μM) [2].
动物实验	Tumors were established in mice for 5 days prior to oral or intraperitoneal treatments with MT-DADMe-ImmA. Mice are treated with an oral dose of 21 mg/kg or an intraperitoneal dose of 5 mg/kg/day MT-DADMe-ImmA [2].
别名	MTDIA, Methylthio-DADMe-Immucillin A

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (170.42 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO