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AS8351

Name: AS8351
Brand: TargetMol
SKU: T4100
Price: 258 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.72%

货号 T4100Cas号 796-42-9

别名 NSC51355, AS-8351, AS 8351

AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。

为众多的药物研发团队赋能，

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AS8351

一键复制产品信息

很棒

纯度: 99.72%

货号 T4100 别名 NSC51355, AS-8351, AS 8351Cas号 796-42-9

AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。

规格	价格	库存
2 mg	¥ 258	现货
5 mg	¥ 396	现货
10 mg	¥ 567	现货
25 mg	¥ 1,120	现货
50 mg	¥ 1,980	现货
100 mg	¥ 3,730	现货
200 mg	¥ 5,330	现货
500 mg	¥ 7,880	现货
1 mL x 10 mM (in DMSO)	¥ 455	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.72%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

AS8351 AI Summary

AS8351 exhibits a broad spectrum of bioactivities. Notably, it shows significant antiproliferative activity against human SK-N-MC cells, with reported IC50 values ranging from 300.0 nM to 2530.0 nM across different studies. In an MTT assay conducted over 72 hours, the IC50 values commonly observed are approximately 710.0 nM and 1300.0 nM. Additionally, AS8351 inhibits iron uptake from transferrin in SK-N-MC cells, demonstrating an inhibition rate of up to 9% at 50 µM, and induces intracellular iron mobilization with an activity level of up to 44.0%. Despite its diverse activities, the compound exhibits weak inhibitory effects against HIV1 reverse transcriptase ribonuclease H, with IC50 values greater than 100,000.0 nM. AS8351 also demonstrates antimicrobial activity against various bacteria and fungi, cytotoxicity against several human cell lines, and antiviral activity against a range of viruses. Additionally, it shows bioactivity as an inhibitor of the interaction between human Flag-tagged LEDGF and His6-tagged HIV1 integrase with an IC50 of 6000.0 nM, but does not affect HIV1 integrase's strand transfer or 3'-processing activities significantly. Lastly, it exhibits antimalarial activity against Plasmodium falciparum 7G8, with an IC50 of 42.2 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
别名	NSC51355, AS-8351, AS 8351

化学信息

分子量	291.3
分子式	C₁₇H₁₃N₃O₂
CAS No.	796-42-9
Smiles	NN(\C=C1/C(=O)C=Cc2ccccc12)C(=O)c1ccncc1
密度	1.364g/cm3

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 37.59 mg/mL (129.04 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4329 mL	17.1644 mL	34.3289 mL	171.6444 mL
5 mM	0.6866 mL	3.4329 mL	6.8658 mL	34.3289 mL
10 mM	0.3433 mL	1.7164 mL	3.4329 mL	17.1644 mL
20 mM	0.1716 mL	0.8582 mL	1.7164 mL	8.5822 mL
50 mM	0.0687 mL	0.3433 mL	0.6866 mL	3.4329 mL
100 mM	0.0343 mL	0.1716 mL	0.3433 mL	1.7164 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。