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Piromidic acid
一键复制产品信息
很棒纯度: 97.29%
货号 T16542Cas号 19562-30-2
别名 吡乙酸三氮萘, 吡咯酸
Piromidic acid 是一种抗菌剂。它对革兰氏阴性菌和葡萄球菌具有活性，可研究肠道，泌尿和胆道感染。
Piromidic acid
一键复制产品信息 很棒纯度: 97.29%
货号 T16542 别名 吡乙酸三氮萘, 吡咯酸Cas号 19562-30-2
Piromidic acid 是一种抗菌剂。它对革兰氏阴性菌和葡萄球菌具有活性，可研究肠道，泌尿和胆道感染。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 10 mg | ¥ 340 | 现货 | |
| 50 mg | ¥ 760 | 现货 | |
| 100 mg | ¥ 1,220 | 现货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
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产品介绍
Piromidic acid AI Summary
Piromidic acid is a versatile bioactive compound exhibiting cytotoxicity against human cancer cell lines and multiple other bioactivities. It has a Maximum Non-Toxic Concentration (MNTC) of 120.0 µM in HepG2 cells, 100.0 µM in HeLa cells, and 250.0 µM in CECH cells, with respective IC50 values of 110 µM, 97 µM, and 184 µM. It demonstrates inhibition of cell proliferation in various assays and has a cytotoxicity ratio of 1.67 for HepG2 cells.
In microbial assays, Piromidic acid shows an MIC of 38.0 µg/mL in Gyrase Induced DNA-Cleavage assays and IC50 greater than 100.0 µg/mL in a supercoiling inhibition assay for E. coli DNA gyrase. Its MIC values against bacteria are 50.0 µg/mL for E. coli (H560), 25.0 µg/mL for E. coli (vogel) and Klebsiella pneumonia (MGH-2), 12.5 µg/mL for Staphylococcus aureus (H228), and over 100.0 µg/mL for Pseudomonas aeruginosa (UI-18) and Streptococcus pneumoniae (SV-1).
The compound also displays 25.0% relaxation in isolated guinea pig trachea and a pD2 value of 5.3 for relaxation potency. In various enzymatic and cell-based assays, it demonstrates potencies ranging from 707.9 nM to over 25,000 nM, with notable activities including the inhibition of Lamin A splicing, Caspase-1, GCN5L2, APE1, and Ebola virus entry.
Piromidic acid inhibits sodium fluorescein uptake significantly in OATP1B1 and OATP1B3-transfected CHO cells, with an inhibition rate of 79.57% and 100.95% respectively at 10 µM, indicating strong OATP inhibitor potential. It has low inhibition of cell viability with an inhibition index of 0.06078.
In antiviral assays, the compound shows varied inhibition of SARS-CoV-2 induced cytotoxicity and 3CL-Pro protease, with some results indicating low or negligible effects at tested concentrations. However, it exhibits potential as a protease inhibitor with 8.107% inhibition of SARS-CoV-2 3CL-Pro at 20 µM and IC50 values greater than 20000.0 nM in certain assays.
Additionally, Piromidic acid has potential HDAC6 inhibitory activity with inhibition percentages of -15.55% in commercial peptide substrate assays and -8.29% in custom peptide substrate assays. It also shows antimalarial activity with IC50 values of 21.6 µg/mL in hepatic stage and 14.4 µg/mL and 41.4 µg/mL in blood stages for different strains of Plasmodium.
Overall, these results suggest Piromidic acid has a diverse range of bioactivities, making it a compound of interest for further research in oncology, antimicrobial, antiviral, and antimalarial fields, as well as in OATP and HDAC6 inhibition studies..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Piromidic acid is an antibacterial agent. Piromidic acid is active against gramnegative bacteria and staphylococci. It is used for urinary tract and intestinal infections. |
| 别名 | 吡乙酸三氮萘, 吡咯酸 |
| 分子量 | 288.3 |
| 分子式 | C14H16N4O3 |
| CAS No. | 19562-30-2 |
| Smiles | CCn1cc(C(O)=O)c(=O)c2cnc(nc12)N1CCCC1 |
| 密度 | 1.4g/cm3 |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| 溶解度信息 | DMSO: 1 mg/mL (insoluble or slightly soluble) H2O: 1 mg/mL (3.47 mM), Sonication and heating to 80℃ are recommended. | ||||||||||
溶液配制表 | |||||||||||
H2O
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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