Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1]. |
体外活性 | LasR-IN-3 (compound 7f) (4.68-150 μg/mL; 24 h) shows anti-activity against Pseudomonas aeruginosa with MIC and sub-MIC values of 56.25 μg/mL and 14.00 μg/mL [1]. LasR-IN-3 (14.00 μg/mL; 24 h, or 48 h) inhibits biofilm formation, pyocyanin, and rhamnolipids production with inhibition rate of 71.70%, 68.70%, 54.00%, respectively [1]. LasR-IN-3 (56.25 μg/mL, and 338.0 μg/mL; 24 h) is safe to normal cell line (HDFa) [1]. LasR-IN-3 (14.00 μg/mL; 24 h) decreases lasR and rhlR gene expression and inhibits the QS-dependent biofilm formation and virulence factors [1]. RT-PCR [1] Cell Line: Pseudomonas aeruginosa Concentration: 14.00 μg/mL Incubation Time: 24 hours Result: Decreased lasR and rhlR expression by 26% and 16.3%, respectively. |
分子量 | 357.41 |
分子式 | C22H19N3O2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LasR-IN-3 Inhibitor inhibitor inhibit