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JX06

Name: JX06
Brand: TargetMol
SKU: T22350
Price: 159 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.4%

货号 T22350Cas号 729-46-4

JX06 是一种选择性共价PDK 抑制剂，抑制PDK1,PDK2和PDK3，IC50值分别为 49 nM，101 nM 和 313 nM。它以不可逆的方式与半胱氨酸残基共价结合来抑制PDK1活性，具有抗肿瘤活性。

为众多的药物研发团队赋能，

让新药发现更简单！

JX06

一键复制产品信息

很棒

纯度: 99.4%

货号 T22350Cas号 729-46-4

规格	价格	库存
1 mg	¥ 159	现货
5 mg	¥ 347	现货
10 mg	¥ 519	现货
25 mg	¥ 987	现货
50 mg	¥ 1,670	现货
100 mg	¥ 2,650	现货
1 mL x 10 mM (in DMSO)	¥ 379	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.4%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

JX06 AI Summary

JX06 exhibits a broad spectrum of bioactivities, demonstrating significant potency across various assays. It inhibits HIV-1 replication in a human T-cell line with an IC50 value of 0.52. Additionally, it inhibits human recombinant FAAH with an IC50 of approximately 79.4 µM and human MGL with an IC50 of 219 nM. The compound also shows over 50% inhibition of MGL activity at 10 µM. Beyond its antiviral activity, JX06 displays antifungal properties against Histoplasma capsulatum, with a minimum inhibitory concentration (MIC) of 40 µg/mL and efficacy in extending the survival of infected mice. Moreover, JX06 demonstrates antitrichomonas activity against Trichomonas vaginalis, with a MIC of 9.6 µM, and exhibits spermicidal activity with a minimum effective concentration of 0.1%. It also shows antifungal activity against several other fungi like Candida albicans and Cryptococcus neoformans with MIC values ranging from 38.4 µM to 76.9 µM. The compound inhibits pyruvate dehydrogenase kinases (PDKs) 1, 2, and 3, with IC50 values of 49 nM, and Ki values of 462 nM, 176 nM, and 2851 nM, respectively. It demonstrates antiproliferative effects on human A549 and Kelly cells, with IC50 values of 480 nM and 289 nM, respectively, and shows antitumor activity in A549 cell xenografts in mice. Additionally, it inhibits ALDH1A1 and ALDH2 with IC50 values of 40 nM and 1430 nM, respectively, and exhibits inhibitory effects on the SARS CoV-2 main protease (IC50 = 4030 nM) and human PHGDH (IC50 = 210 nM). JX06 also inhibits wild-type human liver FBPase by 26.08% at 10 µM. Overall, JX06 shows potential as a multi-target therapeutic agent with inhibitory activities across a range of biological targets, suggesting its applicability in treating various diseases and conditions, including infectious diseases, cancer, and metabolic disorders..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
靶点活性	PDK1:49 nM (IC50), PDK3:313 nM (IC50), PDK2:101 nM (IC50)

化学信息

分子量	324.51
分子式	C₁₀H₁₆N₂O₂S₄
CAS No.	729-46-4
Smiles	S=C(SSC(=S)N1CCOCC1)N1CCOCC1
密度	1.463g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (84.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.16 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0816 mL	15.4078 mL	30.8157 mL	154.0785 mL
5 mM	0.6163 mL	3.0816 mL	6.1631 mL	30.8157 mL
10 mM	0.3082 mL	1.5408 mL	3.0816 mL	15.4078 mL
20 mM	0.1541 mL	0.7704 mL	1.5408 mL	7.7039 mL
50 mM	0.0616 mL	0.3082 mL	0.6163 mL	3.0816 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。