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AZ9482

Name: AZ9482
Brand: TargetMol
SKU: T22264
Price: 453 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.86%

货号 T22264Cas号 1825345-33-2

AZ9482 是一种选择性 PARP1/2/6的三重抑制剂，IC50值分别为 1 、1 和640 nM。

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AZ9482

一键复制产品信息

很棒

纯度: 99.86%

货号 T22264Cas号 1825345-33-2

AZ9482 是一种选择性 PARP1/2/6的三重抑制剂，IC50值分别为 1 、1 和640 nM。

规格	价格	库存
1 mg	¥ 453	现货
5 mg	¥ 1,280	现货
10 mg	¥ 1,990	现货
25 mg	¥ 3,990	现货
50 mg	¥ 5,680	现货
100 mg	¥ 7,930	现货
1 mL x 10 mM (in DMSO)	¥ 1,310	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.86%

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COA LCMS HPLC HNMR 产品操作手册

产品介绍

AZ9482 AI Summary

AZ9482 exhibits various bioactivities, prominently acting as a potent PARP inhibitor with IC50 values ranging from 1.0 nM to 640.0 nM in cellular and biochemical assays. Highlighting its potential as an anti-cancer agent, the compound displays cytotoxicity against human OCI-LY19 cells with an IC50 of 3.0 nM. Furthermore, it inhibits the TNSK1/2-activated Wnt pathway with an IC50 of 222.0 nM, indicating its role in modulating cellular signaling pathways. Additionally, AZ9482 induces centrosome declustering in various cancer cell lines, with EC50 values spanning from 3.0 nM to 123.0 nM. Pharmacokinetic profiles, including solubility, lipophilicity, clearance rates, and distribution volumes, suggest favorable drug-like properties and oral bioavailability in both rat and mouse models. Overall, AZ9482 shows promising bioactivity profiles that warrant further investigation for potential therapeutic applications, particularly in cancer treatment and PARP-related pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.

化学信息

分子量	450.49
分子式	C₂₆H₂₂N₆O₂
CAS No.	1825345-33-2
Smiles	O=C(N1CCN(CC1)c1ncccc1C#N)c1cccc(Cc2n[nH]c(=O)c3ccccc23)c1
密度	1.34 g/cm3 (Predicted)

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (277.48 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.33 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2198 mL	11.0990 mL	22.1981 mL	110.9903 mL
5 mM	0.4440 mL	2.2198 mL	4.4396 mL	22.1981 mL
10 mM	0.2220 mL	1.1099 mL	2.2198 mL	11.0990 mL
20 mM	0.1110 mL	0.5550 mL	1.1099 mL	5.5495 mL
50 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2198 mL
100 mM	0.0222 mL	0.1110 mL	0.2220 mL	1.1099 mL