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Cefuroxime axetil

Name: Cefuroxime axetil
Brand: TargetMol
SKU: T1227
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 头孢呋辛酯, Zinnat, Elobact, Cepazine, Ceftin

货号 T1227Cas号 64544-07-6 一键复制产品信息纯度: 99.61%

很棒

Cefuroxime axetil (Zinnat) 是头孢菌素头孢呋辛的前药和一种广谱抗生素，可抑制几种革兰氏阳性和革兰氏阴性生物。

Cefuroxime axetil

一键复制产品信息

很棒

纯度: 99.61%

货号 T1227Cas号 64544-07-6

别名 头孢呋辛酯, Zinnat, Elobact, Cepazine, Ceftin

Cefuroxime axetil (Zinnat) 是头孢菌素头孢呋辛的前药和一种广谱抗生素，可抑制几种革兰氏阳性和革兰氏阴性生物。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 108	现货
2 mg	¥ 137	现货
5 mg	¥ 198	现货
10 mg	¥ 313	现货
25 mg	¥ 569	现货
50 mg	¥ 853	现货
100 mg	¥ 1,280	现货
500 mg	¥ 3,230	现货
1 mL x 10 mM (in DMSO)	¥ 229	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.61%

颜色: 白色

性状: Solid

资源下载: COA HPLC HNMR 产品操作手册

产品介绍

Cefuroxime axetil AI Summary

Cefuroxime axetil demonstrates a range of biological activities and exhibits several pharmacological properties. It shows a binding constant against human serum albumin (HSA) with a Log K' value of 0.56 and a low human intestinal absorption activity of 0.44% when dosed orally. In antimicrobial evaluations, it exhibits activity against Staphylococcus aureus, Staphylococcus epidermidis, and Salmonella typhi with a minimum inhibitory concentration (MIC) of 8.0 µg/mL, while showing lower efficacy against Bacillus pumilus and Pseudomonas aeruginosa (MIC > 16.0 µg/mL). It also presents varied effectiveness against Streptococcus pneumoniae, with MIC values ranging from <= 0.12 µg/mL to > 4.0 µg/mL for different serotypes and susceptibility to penicillin. Cefuroxime axetil shows signs of moderate liver toxicity with elevated levels of liver enzymes such as ALT, AST, and alkaline phosphatase, and a hepatotoxicity frequency of 20% during clinical trials. It does not significantly interfere with human BSEP, MRP2, and MRP3 but inhibits human MRP4 with an IC50 of 28,000 nM. Regarding antiviral activity, Cefuroxime axetil has a low level of activity against SARS-CoV-2 in Vero E6 cells and inhibits SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 17.81% at 20 µM. However, it shows limited cytotoxicity towards Vero E6 cells with IC50 values greater than 20,000 nM. Lastly, Cefuroxime axetil shows potential as an HDAC6 inhibitor with modest inhibitory activities of -19.77% and -9.84% in enzymatic assays using commercial and custom peptide substrates, respectively. Overall, despite its broad spectrum of activities, it does not exhibit significant bioactivity in assays for binding affinity or agonist/antagonist interactions, with AC50 values exceeding 30,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cefuroxime axetil (Zinnat) is a second generation oral cephalosporin antibiotic.
别名	头孢呋辛酯, Zinnat, Elobact, Cepazine, Ceftin

化学信息

分子量	510.47
分子式	C₂₀H₂₂N₄O₁₀S
CAS No.	64544-07-6
Smiles	CO\N=C(\C(=O)N[C@H]1[C@H]2SCC(COC(N)=O)=C(N2C1=O)C(=O)OC(C)OC(C)=O)c1ccco1
密度	1.61 g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 55 mg/mL (107.74 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.92 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9590 mL	9.7949 mL	19.5898 mL	97.9489 mL
5 mM	0.3918 mL	1.9590 mL	3.9180 mL	19.5898 mL
10 mM	0.1959 mL	0.9795 mL	1.9590 mL	9.7949 mL
20 mM	0.0979 mL	0.4897 mL	0.9795 mL	4.8974 mL
50 mM	0.0392 mL	0.1959 mL	0.3918 mL	1.9590 mL
100 mM	0.0196 mL	0.0979 mL	0.1959 mL	0.9795 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。