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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-LIFR Antibody (1Q643)

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货号 TMAY-03816

别名 leukemia inhibitory factor receptor α, leukemia inhibitory factor receptor alpha

Anti-LIFR Antibody (1Q643) 是一种 Mouse 抗体，靶向 LIFR。Anti-LIFR Antibody (1Q643) 可用于 ELISA。

Anti-LIFR Antibody (1Q643)

Anti-LIFR Antibody (1Q643)

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货号 TMAY-03816 别名 leukemia inhibitory factor receptor α, leukemia inhibitory factor receptor alpha

Anti-LIFR Antibody (1Q643) 是一种 Mouse 抗体，靶向 LIFR。Anti-LIFR Antibody (1Q643) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,689
5日内发货
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产品介绍

生物活性
产品描述
Anti-LIFR Antibody (1Q643) is a Mouse antibody targeting LIFR. Anti-LIFR Antibody (1Q643) can be used in ELISA.
别名leukemia inhibitory factor receptor α, leukemia inhibitory factor receptor alpha
Ig Type
Mouse IgG1
克隆号
1Q643
反应种属
Rat
特异性
Rat LIFR
No cross-reactivity in ELISA with
Human cell lysate (293 cell line)
应用ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat LIFR / CD118 (TMPY-03306; G3V7K2; Met1-Ser829).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Rat LIFR / CD118 protein (TMPY-03306)
抗原种属
Rat
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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