规格

价格

库存

数量

1 mg

¥ 770

现货

5 mg

¥ 1,820

现货

10 mg

¥ 2,980

现货

25 mg

¥ 4,830

现货

50 mg

¥ 6,690

现货

100 mg

¥ 8,870

现货

200 mg

¥ 12,200

现货

1 mL x 10 mM (in DMSO)

¥ 1,490

现货

生物活性

产品描述	2-Deoxy-2-fluoro-L-fucose is a fucosylation inhibitor that inhibits the de novo synthesis of GDP-fucose in mammalian cells, effectively inhibits the proliferation of human cancer and primary endothelial cells, and has potential as an angiogenic therapeutic agent. It also inhibits fucosylation of plant cell wall polysaccharides, particularly affecting the dimerization of the pectin-like polysaccharide RG-II, thereby inhibiting root growth and cell elongation.2-Deoxy-2-fluoro-L-fucose also reduces the phosphorylation of Smad 1/5 and Smad 2 in 4T1 cells.
体外活性	方法：2-Deoxy-2-fluoro-L-fucose （100，250，500 μM）处理 4T1 细胞，裂解物的 Aleuria aurantia 凝集素（AAL）用WesternBlot 检测。结果：2-Deoxy-2-fluoro-L-fucose 降低了所有浓度的 AAL 信号并抑制了岩藻糖基化。方法：2-Deoxy-2-fluoro-L-fucose （100 μM，48小时）处理 4T1 细胞，然后接种活细胞通过迁移测定进行分析；评估 Smad 蛋白，评估调节迁移的信号分子变化。结果：2-Deoxy-2-fluoro-L-fucose 处理的细胞的迁移能力受损并降低了 Smad 1/5 和 Smad 2 的磷酸化。[1]
别名	2-脱氧-2-氟-L-岩藻糖

化学信息

分子量	166.15
分子式	C₆H₁₁FO₄
CAS No.	70763-62-1
Smiles	C[C@H](O)[C@@H](O)[C@@H](O)[C@H](F)C=O
密度	1.335 g/cm3 (Predicted)

储存&溶解度

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (481.49 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (19.86 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0187 mL	30.0933 mL	60.1866 mL	300.9329 mL
5 mM	1.2037 mL	6.0187 mL	12.0373 mL	60.1866 mL
10 mM	0.6019 mL	3.0093 mL	6.0187 mL	30.0933 mL
20 mM	0.3009 mL	1.5047 mL	3.0093 mL	15.0466 mL
50 mM	0.1204 mL	0.6019 mL	1.2037 mL	6.0187 mL
100 mM	0.0602 mL	0.3009 mL	0.6019 mL	3.0093 mL