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Tryptamine

Name: Tryptamine
Brand: TargetMol
SKU: T0647
Price: 131 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.59%

货号 T0647Cas号 61-54-1

别名色胺

Tryptamine 是一种在动物、植物和真菌中发现的单胺生物碱。它含有吲哚环结构，结构类似于色氨酸。在哺乳动物的大脑中发现了微量这种物质，并被认为是一种神经递质或神经调节剂。

Tryptamine

一键复制产品信息

很棒

纯度: 98.59%

货号 T0647 别名色胺Cas号 61-54-1

规格	价格	库存
10 mg	¥ 131	现货
25 mg	¥ 200	现货
50 mg	¥ 285	现货
100 mg	¥ 400	现货
500 mg	¥ 950	5日内发货
1 mL x 10 mM (in DMSO)	¥ 285	现货

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实验操作小课堂

常见问题解答

选择批次:

纯度: 98.59%

颜色: 黄色

性状: Solid

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Tryptamine AI Summary

Tryptamine exhibits a broad spectrum of bioactivities and binding affinities, indicating potential pharmacological applications. It shows significant interaction with various serotonin receptors, particularly with high affinity for 5-HT1D (Ki values of 23.0 nM, 36.0 nM, and 61.0 nM in different assays) and moderate affinity for 5-HT6 (Ki = 70.0 nM). Additionally, it binds to 5-HT1A, 1B, 2C, and 2 receptors (Ki values ranging from 50.0 nM to 10200.0 nM), and exhibits bioactivity at 5-HT7 (Ki = 158.49 nM). Tryptamine shows binding affinity and functional activity towards imidazoline receptor I-2 (Ki = 5400.0 nM), alpha-2 adrenergic receptors (Ki = 19000.0 nM), and presents notable agonistic activity at the TAAR1 receptor (EC50 = 2210.0 nM). In enzymatic assays, Tryptamine demonstrates inhibitory properties against various enzymes including the SARS-CoV-2 3CL-Pro protease (17.65% inhibition at 20 µM), CYP2A family (competitive inhibition with Ki values of 1700.0 nM and 16000.0 nM for CYP2A6 and CYP2A13, respectively), and IDO1 (noncompetitive inhibitor, Ki = 160,000.0 nM). It also shows activity against the human MPO enzyme (IC50 = 770.0 nM) and cathepsin K (IC50 = 15000.0 nM). Furthermore, Tryptamine displays antifungal activity against Candida albicans biofilm formation (MBIC50 = 128.0 µg/mL) and demonstrates antibacterial activities against multiple bacterial strains, although with relatively high MIC values (>51.0 µg/mL). Its potential CNS activity is indicated by its effect on neurotransmitter release (EC50 values of 32.6 nM for serotonin, 164.0 nM for dopamine, and 716.0 nM for norepinephrine). Tryptamine also exhibits modest antiviral activities against SARS-CoV-2 and various virus-induced cytotoxicities at micromolar concentrations. The compound has additional pharmacological effects, including NFkB signaling pathway modulation, cytochrome activity modulation, Nrf2 inhibition, JMJD2A-Tudor domain inhibition, D1 dopamine receptor potentiation, and inhibition of HIV-1 Vif-dependent degradation of human APOBEC3G. It also inhibits mycelial growth of Leptosphaeria maculans and displays varying levels of oxidative stress mitigation (IC50 values from 6000.0 nM to 682000.0 nM). Notable properties of Tryptamine include a binding energy of 7.9 kCal/mol, log P of 1.35, intrinsic water solubility of 80.0 µg/mL, and permeability coefficient logP app = -5.27. Overall, these diverse bioactivities suggest that Tryptamine is a multi-target agent with potential applications across a range of therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neurotransmitter or neuromodulator.
靶点活性	TAAR1 (human):1.08 μM(Ki)
别名	色胺

化学信息

分子量	160.22
分子式	C₁₀H₁₂N₂
CAS No.	61-54-1
Smiles	NCCC1=CNC2=CC=CC=C12
密度	1.16 g/cm3. Temperature:25 °C.

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 245 mg/mL (1529.15 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.48 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2414 mL	31.2071 mL	62.4142 mL	312.0709 mL
5 mM	1.2483 mL	6.2414 mL	12.4828 mL	62.4142 mL
10 mM	0.6241 mL	3.1207 mL	6.2414 mL	31.2071 mL
20 mM	0.3121 mL	1.5604 mL	3.1207 mL	15.6035 mL
50 mM	0.1248 mL	0.6241 mL	1.2483 mL	6.2414 mL
100 mM	0.0624 mL	0.3121 mL	0.6241 mL	3.1207 mL

TCMIP相关数据

中药材来源及性味归经

中药材名称	中药材拉丁名	性	味	归经
黄瓜	Cucumis satious L.	凉	甘	肺, 脾, 胃

所属中药方剂

方剂名称	处方组成	剂型	处方来源
黄瓜根丸	黄瓜,黄连	丸剂	方出《圣惠》卷五十三，名见《普济方》卷一七六。
烧黄瓜丸	黄瓜,黄连,胡黄连,陈皮,鳖甲,柴胡	丸剂	《圣惠》卷八十八。
地黄散8	地龙,黄瓜	散剂	《鲁府禁方》卷二。
纳脐膏1	黄瓜	膏剂	《古今医鉴》卷五引何晴岳方。
青黄散2	青鱼胆,黄瓜,梅花,冰片	散剂	《梅氏验方新编》卷一。
徐神翁神效地仙方	川乌,草乌,荆芥,苍术,自然铜,白芷,地龙,没药,乳香,莴苣,黄瓜,木鳖子,钱文,梢瓜	丸剂	《瑞竹堂方》卷二。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Tryptamine TRPVChannel TRPV Channel TRPChannel TRP Channel Inhibitor inhibit hTRPA1 EndogenousMetabolite Endogenous Metabolite AADH 5HTReceptor 5HT Receptor 5-HT

Tryptamine

Tryptamine

Tryptamine 相关产品

产品介绍

TCMIP相关数据

计算器

体内实验配液计算器

剂量转换

引用文献

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