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7-Hydroxyflavone

Name: 7-Hydroxyflavone
Brand: TargetMol
SKU: T7472
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 7-羟基黄酮, 7羟基黄酮

货号 T7472Cas号 6665-86-7 一键复制产品信息纯度: 99.79%

很棒

7-Hydroxyflavone 是一种黄酮类化合物，从M. indica 中分离得到，具有抗炎活性。它利用 ERK/Nrf2/HO-1 通路保护肾细胞，使其免受尼古丁诱导的细胞毒性。

7-Hydroxyflavone

一键复制产品信息

很棒

纯度: 99.79%

货号 T7472Cas号 6665-86-7

别名 7-羟基黄酮, 7羟基黄酮

7-Hydroxyflavone 是一种黄酮类化合物，从M. indica 中分离得到，具有抗炎活性。它利用 ERK/Nrf2/HO-1 通路保护肾细胞，使其免受尼古丁诱导的细胞毒性。

规格	价格	库存
10 mg	¥ 119	现货
25 mg	¥ 167	现货
50 mg	¥ 226	现货
100 mg	¥ 314	现货
500 mg	¥ 727	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.79%

颜色: 白色至灰色

性状: Solid

资源下载: COA HNMR HPLC产品操作手册

产品介绍

7-Hydroxyflavone AI Summary

7-Hydroxyflavone demonstrates a variety of bioactivities across multiple biological assays. It shows inhibitory activity against ALR2 (aldose reductase) with an IC50 value of 14650.0 nM in bovine lenses and against COX-2 catalyzed PGE-2 production in LPS induced RAW 264.7 cells with a 70.8% inhibition rate at 10 µM concentration. It binds to benzodiazepine receptors with a Ki value of 4200.0 nM and interacts with the androgen receptor with an IC50 value greater than 42657.95 nM. Additionally, it shows significant inhibitory activity against hamster liver mitochondrial monoamine oxidase (MAO) with an IC50 of 120.0 nM. 7-Hydroxyflavone also displays low affinity for adenosine A1 and A2A receptors, with pKi values of -0.48 and -0.43 µM, respectively. It effectively lowers systolic blood pressure in anesthetized spontaneously hypertensive rats and provides significant protection from gastric damage in rats. Moreover, it inhibits bovine thymus p56Lck-catalyzed phosphorylation and beef heart mitochondrial enzymes, including a 95.1% inhibition of ATPase activity at 0.42 mM concentration. The compound has shown antiplasmodial activity with an IC50 of 65500.0 nM against Plasmodium falciparum NF54 and also inhibits FabZ enzyme with an IC50 of 20000.0 nM. It demonstrates antioxidant activity by inhibiting toxin-induced lipid peroxidation and shows inhibitory effects on carbonic anhydrase isozymes. 7-Hydroxyflavone induces adipogenesis in mouse 3T3L1 cells and exhibits vasorelaxant properties in Wistar rat thoracic aortic rings. It also shows antagonist activity at the alpha1-adrenoceptor in rat anococcygeal muscle and antiviral activity against Marburg virus and SARS-CoV-2. 7-Hydroxyflavone inhibits human 17beta-HSD1 and 17beta-HSD2 enzymes, demonstrating potential effects in hormone regulation. Furthermore, it exhibits cytotoxicity against human cell lines and moderate inhibition against multiple CYP enzymes, suggesting broad pharmacological properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity
别名	7-羟基黄酮, 7羟基黄酮

化学信息

分子量	238.24
分子式	C₁₅H₁₀O₃
CAS No.	6665-86-7
Smiles	Oc1ccc2c(c1)oc(cc2=O)-c1ccccc1
密度	1.340 g/cm3 at 20℃

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 47 mg/mL (197.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.39 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	209.8724 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL
20 mM	0.2099 mL	1.0494 mL	2.0987 mL	10.4936 mL
50 mM	0.0839 mL	0.4197 mL	0.8395 mL	4.1974 mL
100 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。