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7-Hydroxyflavone

Name: 7-Hydroxyflavone
Brand: TargetMol
SKU: T7472
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.79%

货号 T7472Cas号 6665-86-7

别名 7-羟基黄酮, 7羟基黄酮

7-Hydroxyflavone 是一种黄酮类化合物，从M. indica 中分离得到，具有抗炎活性。它利用 ERK/Nrf2/HO-1 通路保护肾细胞，使其免受尼古丁诱导的细胞毒性。

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7-Hydroxyflavone

一键复制产品信息

很棒

纯度: 99.79%

货号 T7472 别名 7-羟基黄酮, 7羟基黄酮Cas号 6665-86-7

7-Hydroxyflavone 是一种黄酮类化合物，从M. indica 中分离得到，具有抗炎活性。它利用 ERK/Nrf2/HO-1 通路保护肾细胞，使其免受尼古丁诱导的细胞毒性。

规格	价格	库存
10 mg	¥ 119	现货
25 mg	¥ 167	现货
50 mg	¥ 226	现货
100 mg	¥ 314	现货
500 mg	¥ 727	现货

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产品介绍

7-Hydroxyflavone AI Summary

7-Hydroxyflavone demonstrates a variety of bioactivities across multiple biological assays. It shows inhibitory activity against ALR2 (aldose reductase) with an IC50 value of 14650.0 nM in bovine lenses and against COX-2 catalyzed PGE-2 production in LPS induced RAW 264.7 cells with a 70.8% inhibition rate at 10 µM concentration. It binds to benzodiazepine receptors with a Ki value of 4200.0 nM and interacts with the androgen receptor with an IC50 value greater than 42657.95 nM. Additionally, it shows significant inhibitory activity against hamster liver mitochondrial monoamine oxidase (MAO) with an IC50 of 120.0 nM. 7-Hydroxyflavone also displays low affinity for adenosine A1 and A2A receptors, with pKi values of -0.48 and -0.43 µM, respectively. It effectively lowers systolic blood pressure in anesthetized spontaneously hypertensive rats and provides significant protection from gastric damage in rats. Moreover, it inhibits bovine thymus p56Lck-catalyzed phosphorylation and beef heart mitochondrial enzymes, including a 95.1% inhibition of ATPase activity at 0.42 mM concentration. The compound has shown antiplasmodial activity with an IC50 of 65500.0 nM against Plasmodium falciparum NF54 and also inhibits FabZ enzyme with an IC50 of 20000.0 nM. It demonstrates antioxidant activity by inhibiting toxin-induced lipid peroxidation and shows inhibitory effects on carbonic anhydrase isozymes. 7-Hydroxyflavone induces adipogenesis in mouse 3T3L1 cells and exhibits vasorelaxant properties in Wistar rat thoracic aortic rings. It also shows antagonist activity at the alpha1-adrenoceptor in rat anococcygeal muscle and antiviral activity against Marburg virus and SARS-CoV-2. 7-Hydroxyflavone inhibits human 17beta-HSD1 and 17beta-HSD2 enzymes, demonstrating potential effects in hormone regulation. Furthermore, it exhibits cytotoxicity against human cell lines and moderate inhibition against multiple CYP enzymes, suggesting broad pharmacological properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity
别名	7-羟基黄酮, 7羟基黄酮

化学信息

分子量	238.24
分子式	C₁₅H₁₀O₃
CAS No.	6665-86-7
Smiles	Oc1ccc2c(c1)oc(cc2=O)-c1ccccc1
密度	1.340 g/cm3 at 20℃
颜色	Gray
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 47 mg/mL (197.28 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.39 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1974 mL	20.9872 mL	41.9745 mL	209.8724 mL
5 mM	0.8395 mL	4.1974 mL	8.3949 mL	41.9745 mL
10 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9872 mL
20 mM	0.2099 mL	1.0494 mL	2.0987 mL	10.4936 mL
50 mM	0.0839 mL	0.4197 mL	0.8395 mL	4.1974 mL
100 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL