规格

价格

库存

数量

1 mg

¥ 233

待询

2 mg

¥ 329

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5 mg

¥ 538

待询

10 mg

¥ 788

待询

25 mg

¥ 1,620

待询

50 mg

¥ 2,660

待询

1 mL x 10 mM (in DMSO)

¥ 590

现货

生物活性

产品描述	BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
靶点活性	LXRα:68nM, LXRβ:14 nM
体外活性	BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).
体内活性	BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].
别名	XL-652, XL652, XL 652, EXEL04286652, BMS-788

化学信息

分子量	509.06
分子式	C₂₈H₂₉ClN₂O₃S
CAS No.	918348-67-1
Smiles	CC(C)(O)c1cn(c(n1)C(C)(C)c1ccccc1Cl)-c1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
密度	1.21 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (117.86 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.91 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO