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BAY885

Name: BAY885
Brand: TargetMol
SKU: T10479
Price: 737 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.83%

货号 T10479Cas号 2307249-33-6

BAY885 是选择性 ERK5抑制剂，IC50为 35 nM。

为众多的药物研发团队赋能，

让新药发现更简单！

BAY885

一键复制产品信息

很棒

纯度: 99.83%

货号 T10479Cas号 2307249-33-6

BAY885 是选择性 ERK5抑制剂，IC50为 35 nM。

规格	价格	库存
1 mg	¥ 737	现货
5 mg	¥ 1,620	现货
10 mg	¥ 2,690	现货
25 mg	¥ 4,390	现货
50 mg	¥ 6,220	现货
1 mL x 10 mM (in DMSO)	¥ 1,830	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.83%

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COA HPLC HNMR 产品操作手册

产品介绍

BAY885 AI Summary

BAY885 demonstrates significant bioactivities related to the inhibition of specific enzymes and cellular processes. It inhibits His-tagged MAP2K5 activated ERK5 with an IC50 of 35.0 nM and ERK5 in human SN12C cells as measured by MEF2 transcription with IC50 and IC90 values of 115.0 nM and 691.0 nM, respectively. Additionally, it inhibits rat FER, human EPHB3, and human EPHA5 with inhibition rates of 62.0%, 58.0%, and 43.0%, respectively. Despite its potent enzymatic inhibition, it has low cytotoxicity against human SN12C-CMV-Luc cells (IC50 > 30000.0 nM), indicating selective targeting. BAY885 also shows varied effects on cell viability, as a growth rate of 0.0 and 1.0 was observed in HEK293T cells, U2OS cells, and human fibroblasts, suggesting complex bioactivity across different cell lines. Thermal Shift Assays reveal that BAY885 affects protein domain stability, showing both stabilizing and destabilizing effects on different regions. It exhibits high potency in targeting MAPK7 (ERK5) with an IC50 of 35.0 nM in a biochemical affinity assay and in cellular contexts, making it a significant inhibitor of the MAPK7 enzyme. However, it shows low activity against various other kinases and moderate activity against SIGMAR1. Overall, BAY885 appears to intricately influence kinase signaling pathways and cellular processes regulated by ERK5 and related enzymes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BAY885 is a new ERK5 inhibitor.
靶点活性	ERK5:35 nM (IC50)

化学信息

分子量	515.53
分子式	C₂₅H₂₈F₃N₇O₂
CAS No.	2307249-33-6
Smiles	CN1CCN(CC1)c1cnc2c(ncnc2c1)C1CCN(CC1)C(=O)c1ccc(OC(F)(F)F)cc1N
密度	1.362 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 16.67 mg/mL (32.34 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.94 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9398 mL	9.6988 mL	19.3975 mL	96.9876 mL
5 mM	0.3880 mL	1.9398 mL	3.8795 mL	19.3975 mL
10 mM	0.1940 mL	0.9699 mL	1.9398 mL	9.6988 mL
20 mM	0.0970 mL	0.4849 mL	0.9699 mL	4.8494 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。