store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lenumlostat 是一种可口服且具有选择性和有效性的赖氨酰氧化酶样蛋白 2 (LOXL2) 抑制剂,对 hLOXL2 、 hLOXL3 和 LOXL2 具有抑制作用,可用于研究纤维性疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,160 | 现货 | ||
5 mg | ¥ 5,390 | 现货 | ||
10 mg | ¥ 7,890 | 现货 | ||
25 mg | ¥ 11,700 | 现货 | ||
50 mg | ¥ 15,800 | 现货 | ||
100 mg | ¥ 21,300 | 现货 | ||
500 mg | ¥ 42,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 5,950 | 现货 |
产品描述 | Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases. |
靶点活性 | LOXL2:0.10 μM (Mouse), LOXL3 (human):1.17 μM, LOXL2 (human):0.71 μM, LOXL2:0.12 μM (Rat), LOXL2:0.16 μM (Dog) |
体外活性 | Lenumlostat(PAT-1251)is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 μM and 1.17 μM for hLOXL2 and hLOXL3, respectively. It also potently inhibits LOXL2 in mouse, rat, and dog, with IC50s of 0.10 μM, 0.12 μM, and 0.16 μM, respectively. Lenumlostat(PAT-1251) exhibits high selectivity for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO). Additionally, it shows selectivity against the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with less than 10% inhibition at 10 μM[1]. |
别名 | PAT-1251, GB2064 |
分子量 | 399.34 |
分子式 | C18H17F4N3O3 |
CAS No. | 2098884-52-5 |
store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (200.33 mM), Sonication is recommended.
H2O: 80 mg/mL (200.33 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.5041 mL | 12.5207 mL | 25.0413 mL | 62.6033 mL |
5 mM | 0.5008 mL | 2.5041 mL | 5.0083 mL | 12.5207 mL | |
10 mM | 0.2504 mL | 1.2521 mL | 2.5041 mL | 6.2603 mL | |
20 mM | 0.1252 mL | 0.626 mL | 1.2521 mL | 3.1302 mL | |
50 mM | 0.0501 mL | 0.2504 mL | 0.5008 mL | 1.2521 mL | |
100 mM | 0.025 mL | 0.1252 mL | 0.2504 mL | 0.626 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lenumlostat 2098884-52-5 Neuroscience Monoamine Oxidase PAT-1251 GB2064 Inhibitor inhibitor inhibit