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TargetMol | Compound Library

DNA 损伤和修复分子库现货

DNA Damage & Repair Compound Library
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货号 L3900

癌细胞的耐药性是癌症治疗过程中面临的主要挑战，因此鉴定新的生物学靶标，并开发设计相应的药物成为重要策略，在各种潜在候选靶标中，癌细胞 DNA Damage & Repair 系统是重要的靶标。由于抗生素的滥用，细菌等微生物的耐药性越来越强，开发靶向微生物 DNA Damage & Repair 系统的药物迫在眉睫。

TargetMol DNA 损伤和修复分子库是1440 个与DNA 损伤和修复紧密相关的化合物集合，可用于DNA 损伤和修复相关研究的高通量筛选，高内涵筛选。

TargetMol 的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。
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货号 L3900

DNA 损伤和修复分子库

规格

  • 1 mg
  • 10 μL x 10 mM (in DMSO)
  • 20 μL x 10 mM (in DMSO)
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
询价 & 定制

产品描述 产品描述

  • 1440个与DNA损伤和修复紧密相关的化合物集合，是高通量筛选，高内涵筛选的良好载体；
  • 涵盖与DNA损伤和修复相关的热门靶点，如HDAC、DNA/RNA Synthesis、Topoisomerase等；
  • 通过临床前研究和临床实验，生物活性和生物安全性得到保障；
  • 结构多样，药效显著，可渗透细胞；
  • 详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确，纯度高，减少假阳性。

包装和储存 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管；
  • 干粉蓝冰运输，DMSO溶液干冰运输；
  • 排布：96孔板：1st & 12th 空白对照，384孔板：1st & 2nd & 23th & 24th空白对照。
  • 本化合物库通常以 DMSO 10 mM 浓度提供。少量产品可能因溶解性或稳定性需求，采用其他溶剂或浓度包装，具体以实际产品信息为准。

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化合物库操作手册 (635 KB) Targetmol化合物库目录 (60.2 MB)

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Library Customization | TargetMol 化合物库组成

DNA/RNA Synthesis
Apoptosis
PPAR
HDAC
Nucleoside Antimetabolite/Analog
PARP
Topoisomerase
Autophagy
Antibacterial
Endogenous Metabolite
Antibiotic
Sirtuin
DUB
NF-κB
Caspase
ROS
Parasite
PI3K
Virus Protease
DNA-PK
ATM/ATR
DNA Alkylator/Crosslinker
Akt
HIV Protease
mTOR
DHFR
Dehydrogenase
Influenza Virus
DNA
COX
AMPK
Antifungal
Reactive Oxygen Species
HSV
Bcl-2 Family
p38 MAPK
Interleukin
Wnt/beta-catenin
DNA Alkylation
STAT
SARS-CoV
ERK
Antifolate
Telomerase
MDM-2/p53
Antiviral
JNK
TNF
CDK
DNA gyrase
Mitophagy
Ferroptosis
Cytochromes P450
HCV Protease
Nrf2
ADC Cytotoxin
PKC
p53
HBV
Prostaglandin Receptor
Epigenetic Reader Domain
TGF-beta/Smad
Mitochondrial Metabolism
IL Receptor
MMP
Potassium Channel
Antioxidant
Adenosine Receptor
Reverse Transcriptase
GABA Receptor
PDE
NO Synthase
CRISPR/Cas9
Drug Metabolite
Tyrosinase
JAK
Ras
Antifection
Anti-infection
Phosphatase
Calcium Channel
HSP
AChR
HIF/HIF Prolyl-Hydroxylase
EGFR
BMI-1
DNA Methyltransferase
Pyroptosis
PKA
Gamma-secretase
Lipoxygenase
Microtubule Associated
TRP/TRPV Channel
transporter
MEK
P-gp
TLR
GSK-3
IκB/IKK
MAPK
Sodium Channel
Bcr-Abl
Adrenergic Receptor
Beta Amyloid
FLT
NOD-like Receptor (NLR)
Monoamine Oxidase
RAAS
Glucosidase
MicroRNA
VEGFR
MTH1
KLF
Src
ABC Transporter
IGF-1R
GPCR
c-Myc
Histone Acetyltransferase
Raf
CaMK
Glutathione Peroxidase
Cysteine Protease
Leukotriene Receptor
OXPHOS
LRRK2
Cannabinoid Receptor
Proteasome
Hedgehog/Smoothened
Phospholipase
Cell Cycle Arrest
Immunology/Inflammation related
Angiotensin-converting Enzyme (ACE)
Syk
PROTACs
Carbonic Anhydrase
Histone Demethylase
Tyrosine Kinases
glycosidase
cGAS
Casein Kinase
ribosome
NOD
Histone Methyltransferase
Fatty Acid Synthase
Aurora Kinase
FAK
Transferase
NUDIX hydrolase
IFNAR
Necroptosis
IDO
5-HT Receptor
S6 Kinase
Thrombin
NOS
Serine/threonin kinase
FXR
FABP
LDL
Free radical scavengers
Acetyl-CoA Carboxylase
Retinoid Receptor
Integrin
Reductase
Histamine Receptor
FLAP
Liposome
PAFR
Chk
PI4K
PLK
ATPase
PERK
IAP
E1/E2/E3 Enzyme
Cholinesterase (ChE)
Mdm2
Arginase
c-Met/HGFR
PAK
ALK
Carboxypeptidase
ROS Kinase
PD-1/PD-L1
Androgen Receptor
Indoleamine 2,3-Dioxygenase (IDO)
PGE Synthase
Aminopeptidase
Methionine Adenosyltransferase (MAT)
HMG-CoA Reductase
Kras
YAP
BACE
NADPH
OCT
Bcl-6
ROCK
Molecular Glues
Lipid
PDK
SGK
c-Kit
Proton pump
MyD88
Aryl Hydrocarbon Receptor
Prolyl Endopeptidase (PREP)
PTEN
Xanthine Oxidase
Epoxide Hydrolase
Huntingtin
STING
MLK
Estrogen Receptor/ERR
Beta-Secretase
Adenosine Deaminase
c-RET
TAM Receptor
Amino Acids and Derivatives
Ligands for Target Protein for PROTAC
P2Y Receptor
Serine Protease
Glucokinase
NMDAR
Orphan Receptor
Trk receptor
GPCR19
RSV
c-Fms
VDAC
ATG
iGluR
Monoamine Transporter
PDGFR
FAAH
CCR
GluR
Hydroxylase
Sigma receptor
CFTR
HER
gp120/CD4
GTPase
Photosensitizer
MAO
cAMP
Ephrin Receptor
CPT
Aromatase
HIF
Platelet aggregation
Dopamine Receptor
Estrogen/progestogen Receptor
MRP
Adenylate cyclase
UGT
P2X Receptor
PAD
Survivin
Drug-Linker Conjugates for ADC

Keywords

肿瘤拓扑异构酶抑制剂拓扑异构酶同源重组碱基切除修复基因组学基因组稳定性化合物库核苷酸切除修复高通量筛选非同源末端连接单链断裂错配修复癌症治疗癌症TumorTopoisomerase inhibitorTopoisomeraseSSBSmall molecule compoundsSingle-strand breakPARP抑制剂PARP inhibitorPARPNucleotide excision repairNon-homologous end joiningNHEJNERMolecule libraryMMRMismatch repairHRHomologous recombinationHigh-throughput screeningGenomicsGenomic stabilityDSBDNA修复DNA损伤DNA双链断裂DNA-PKDNA 损伤和修复分子库DNA repairDNA double-strand breakDNA Damage and Repair Molecule LibraryDNA damageCancer therapyCancerBERBase excision repairATRATM