Cephalomannine

Name: Cephalomannine
Brand: TargetMol
SKU: T2217
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.75%

货号 T2217Cas号 71610-00-9

别名 三尖杉宁碱, Baccatin III

Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物，具有抗肿瘤活性，可用于癌症研究。

Cephalomannine

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很棒

纯度: 99.75%

货号 T2217 别名 三尖杉宁碱, Baccatin IIICas号 71610-00-9

Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物，具有抗肿瘤活性，可用于癌症研究。

规格	价格	库存
2 mg	¥ 136	现货
5 mg	¥ 197	现货
10 mg	¥ 268	现货
25 mg	¥ 426	现货
50 mg	¥ 613	现货
100 mg	¥ 896	现货
500 mg	¥ 2,190	现货
1 mL x 10 mM (in DMSO)	¥ 350	现货

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产品介绍

Cephalomannine AI Summary

Cephalomannine exhibits a binding affinity to microtubules, with an activity expressed as an ID50 ratio of 1.5 compared to paclitaxel. It demonstrates broad cytotoxic and antiproliferative activity against various human cancer cell lines, including MCF7, HCT8, Bel7402, BGC823, A549, A2780, and KB cells, with IC50 values ranging from 4.0 nM to 920.0 nM. Specifically, it shows potent cytotoxicity against human MCF7 cells with an IC50 of 6.0 nM after 72 hours and KB cells with an ED50 of 3.8 x 10^-3 ug/mL. Cephalomannine also exhibits in vivo antitumor activity against mouse P388 cells at doses of 1 to 3.3 mg/kg, with a Tumor Control (T/C) value of up to 162.0%. Furthermore, it induces tubulin assembly in bovine brain at specific concentrations, with ED50 values of 0.95 uM and 0.85 uM, indicating its mechanism of action is comparable to Taxol. The compound also shows toxicity on brine shrimp with an LC50 of 0.81 ug/mL after 24 hours. Additionally, it has demonstrated antiproliferative effects against mouse NIH/3T3 cells with an IC50 of 600.0 nM and reduced efficacy against A2780/TAX, HCT8, and HCT8/VCT cell lines..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
别名	三尖杉宁碱, Baccatin III

化学信息

分子量	831.9
分子式	C₄₅H₅₃NO₁₄
CAS No.	71610-00-9
Smiles	C\C=C(/C)C(=O)N[C@H]([C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C)OC(C)=O)c1ccccc1
密度	1.36 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 93 mg/mL (111.79 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (111.79 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.97 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.2021 mL	6.0103 mL	12.0207 mL	60.1034 mL
5 mM	0.2404 mL	1.2021 mL	2.4041 mL	12.0207 mL
10 mM	0.1202 mL	0.6010 mL	1.2021 mL	6.0103 mL
20 mM	0.0601 mL	0.3005 mL	0.6010 mL	3.0052 mL
50 mM	0.0240 mL	0.1202 mL	0.2404 mL	1.2021 mL
100 mM	0.0120 mL	0.0601 mL	0.1202 mL	0.6010 mL