规格

价格

库存

数量

25 mg

¥ 292

现货

50 mg

¥ 418

现货

100 mg

¥ 587

现货

500 mg

¥ 1,449

现货

生物活性

产品描述	Meropenem (SM 7338) is a synthetic carbapenem antibiotic with broad-spectrum antibacterial activity. It exerts a bactericidal effect by inhibiting the synthesis of peptidoglycan in the bacterial cell wall and is active against a wide range of Gram-positive, Gram-negative, and anaerobic bacteria. Meropenem is active against both susceptible and resistant Neisseria gonorrhoeae (MIC values of 0.02–0.06 mg/mL), Haemophilus influenzae (MIC: 0.03–0.12 mg/mL), and Klebsiella pneumoniae (MIC: 0.015–0.12 mg/mL). Meropenem can be used for constructing bacterial infection models and screening for antimicrobial activity.
靶点活性	E. coli:0.19 µg/mL (MIC), N. gonorrhoeae:0.02-0.06 mg/mL (MIC), H. ducreyi:0.015-0.12 mg/mL (MIC), K. pneumoniae isolates:⩽ 32 mg/L (MIC), H. influenzae:0.03-0.12 mg/mL (MIC)
体外活性	方法：产 NDM-1 的大肠杆菌 ZC-YN3 临床分离株以及产 NDM-5、NDM-9 的菌株加入 Meropenem 单药或厚朴酚单药或 Meropenem + 厚朴酚（32 μg/mL）联用，检测最低抑菌浓度（MIC）。结果： Meropenem 单药 MIC：16 μg/mL （对 ZC-YN3），厚朴酚单药 MIC：>1024 μg/mL （无直接抗菌活性），Meropenem+厚朴酚联用 MIC：4 μg/mL （对 ZC-YN3），降低 4 倍。[1] 方法：人类原代肺泡上皮细胞（HPAEpiC），经 FlexCell 系统模拟机械拉伸后感染 PAO1 菌株。在感染后 2 小时加入药物加入 Meropenem （5 × MIC，0.5 × MIC），在感染后 4 小时和 8 小时评估细菌载量。结果：Meropenem 有效减少细菌载量。[2]
体内活性	方法：C57BL/6J 小鼠，机械通气后经气管感染 PAO1 菌株，感染 4 小时和 16 小时后各给药一次，腹腔注射 Meropenem 单药。结果：Meropenem 单药能显著降低肺部及全身细菌载量[2]
激酶实验	Complementation of SCR7 Inhibition with Puri?ed Ligase IV: Complementation experiment is carried out by adding increasing concentrations of puri?ed Ligase IV/XRCC4 complex (30, 60, and 120 fmol) along with the oligomeric DNA substrates (5' compatible and 5'-5' noncompatible ends) to the SCR7-treatedextracts. Reactions are incubated for 2 h at 25℃. The reaction products are then resolved on 8% denaturing PAGE. The gel is dried and exposed and the signal is detected with a PhosphorImager and analyzed with Multi Gauge (V3.0) software.
别名	美罗培南, SM 7338

化学信息

分子量	383.46
分子式	C₁₇H₂₅N₃O₅S
CAS No.	96036-03-2
Smiles	C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])([C@@H](C)C1S[C@H]3C[C@@H](C(N(C)C)=O)NC3)[H]
密度	1.42 g/cm3 (Predicted)

储存&溶解度

存储

Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (260.78 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 5 mg/mL (13.04 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.43 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6078 mL	13.0392 mL	26.0783 mL	130.3917 mL
5 mM	0.5216 mL	2.6078 mL	5.2157 mL	26.0783 mL
10 mM	0.2608 mL	1.3039 mL	2.6078 mL	13.0392 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1304 mL	0.6520 mL	1.3039 mL	6.5196 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6078 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3039 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Meropenem

Meropenem

产品介绍

引用文献

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体内实验配液计算器

剂量转换

关键词

Meropenem

Meropenem

Meropenem 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词