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FGH10019

Name: FGH10019
Brand: TargetMol
SKU: T7798
Price: 653 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.93%

货号 T7798Cas号 1046045-61-7

别名 FGH-10019

FGH10019 是固醇调节元件结合蛋白 (SREBP) 抑制剂，IC50=1 μM。

为众多的药物研发团队赋能，

让新药发现更简单！

FGH10019

一键复制产品信息

很棒

纯度: 98.93%

货号 T7798 别名 FGH-10019Cas号 1046045-61-7

FGH10019 是固醇调节元件结合蛋白 (SREBP) 抑制剂，IC50=1 μM。

规格	价格	库存
1 mg	¥ 653	现货
5 mg	¥ 1,630	现货
10 mg	¥ 2,250	现货
25 mg	¥ 3,550	现货
50 mg	¥ 5,010	现货
100 mg	¥ 6,720	现货
200 mg	¥ 8,880	现货
1 mL x 10 mM (in DMSO)	¥ 1,380	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 98.93%

颜色: 黄色

性状: solid

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

FGH10019 AI Summary

FGH10019 exhibits numerous bioactivities, including significant inhibition of SREBP2 activation, which leads to the down-regulation of various genes involved in lipid metabolism such as stearoyl-CoA desaturase, MVK, HMG-CoA reductase, ATP citrate lyase, INSIG1, HMG-CoA synthase 1, isopentenyl diphosphate delta isomerase 1, and LDLR. The compound also exhibits antiobese activity in ob/ob C57BL/6J mice with positive effects on body weight, serum glucose, serum cholesterol, serum HDL and LDL levels, liver triglyceride levels, and a reduction in food intake. FGH10019 shows good aqueous solubility at both pH 3 and pH 7, favorable intrinsic clearance, acceptable half-life in mouse hepatocytes, and significant apparent permeability in PAMPA assays. In addition, FGH10019 displays potent antimicrobial activity against various clinical isolates of Mycobacterium tuberculosis, including some resistant strains, with low inhibitory concentrations (MIC < 0.5 µg/mL) observed after 7 days of exposure. It demonstrates good solubility (1300.0 nM), low unbound fraction in mouse plasma (Fu < 0.01), and moderate intrinsic clearance in both mouse liver microsomes (CL = 28.84 mL.min-1.g-1) and human liver microsomes (CL = 4.3 mL.min-1.g-1). Furthermore, in a luciferase reporter assay conducted in CHO-K1 cells, FGH10019 inhibits SREBP with an IC50 value of 700.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	FGH10019 is a novel inhibitor of sterol regulatory element-binding protein (SREBP) ( IC50 :1 μM).
靶点活性	SREBP:1 μM
别名	FGH-10019

化学信息

分子量	373.49
分子式	C₁₈H₁₉N₃O₂S₂
CAS No.	1046045-61-7
Smiles	CCCc1cc(ccn1)-c1nc(cs1)-c1ccc(NS(C)(=O)=O)cc1
密度	1.307 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 38 mg/mL (101.74 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6774 mL	13.3872 mL	26.7745 mL	133.8724 mL
5 mM	0.5355 mL	2.6774 mL	5.3549 mL	26.7745 mL
10 mM	0.2677 mL	1.3387 mL	2.6774 mL	13.3872 mL
20 mM	0.1339 mL	0.6694 mL	1.3387 mL	6.6936 mL
50 mM	0.0535 mL	0.2677 mL	0.5355 mL	2.6774 mL
100 mM	0.0268 mL	0.1339 mL	0.2677 mL	1.3387 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。