Methoxyfenozide

Name: Methoxyfenozide
Brand: TargetMol
SKU: T19821
Price: 109 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.59%

货号 T19821Cas号 161050-58-4

别名 甲氧虫酰肼

Methoxyfenozide 是一种二酰基肼类杀虫剂，其与鳞翅类蜕皮激素受体 (EcRs) 结合 (Kd=0.5 nM) 比对二萜 EcRs 结合 (Kd=124 nM) 的选择性高。

Methoxyfenozide

一键复制产品信息

很棒

纯度: 99.59%

货号 T19821 别名 甲氧虫酰肼Cas号 161050-58-4

Methoxyfenozide 是一种二酰基肼类杀虫剂，其与鳞翅类蜕皮激素受体 (EcRs) 结合 (Kd=0.5 nM) 比对二萜 EcRs 结合 (Kd=124 nM) 的选择性高。

规格	价格	库存
5 mg	¥ 109	现货
10 mg	¥ 147	现货
25 mg	¥ 239	现货
50 mg	¥ 347	现货
100 mg	¥ 598	现货
500 mg	¥ 1,480	现货
1 mL x 10 mM (in DMSO)	¥ 239	现货

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纯度: 99.59%

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资源下载:

COA HNMR LCMS HPLC 产品操作手册

产品介绍

Methoxyfenozide AI Summary

Methoxyfenozide exhibits a wide range of bioactivities, including insecticidal, antifeedant, and receptor modulation properties. It shows significant potency as an agonist at ecdysone receptors in various insect species, such as Bombyx mori and Choristoneura fumiferana, with EC50 values of 100.0 nM and 280.0 nM, respectively. The compound demonstrates high permeability through artificial membranes, with a Papp value of 19.06 x 10^-6 cm/s, and has favorable logP values indicating good bioavailability. In addition to its receptor modulation, Methoxyfenozide has shown toxicity against several insect pests such as the European corn borer, diamondback moth, Helicoverpa armigera, and Oriental armyworm, achieving 100% mortality at specific concentrations. It also reduces the fecundity and increases mortality rates of mites and codling moths, with high potency against both susceptible and resistant strains. Methoxyfenozide also activates various signaling pathways in mammalian cells, including the vitamin D receptor and antioxidants response element signaling pathways, suggesting potential therapeutic applications. It exhibits significant human pregnane X receptor modulation with a potency of 7.9 μM. Additionally, Methoxyfenozide shows antiviral activity, inhibiting SARS-CoV-2 3CL-Pro protease by 11.51% at 20 μM and reducing virus-induced cytotoxicity in VERO-6 cells at a 10 μM concentration. Overall, Methoxyfenozide demonstrates broad-spectrum bioactivities, making it a promising candidate for both pest control and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Methoxyfenozide is an insect growth regulator. Methoxyfenozide used in the control of lepidopteran insect pests.
别名	甲氧虫酰肼

化学信息

分子量	368.47
分子式	C₂₂H₂₈N₂O₃
CAS No.	161050-58-4
Smiles	COc1cccc(C(=O)NN(C(=O)c2cc(C)cc(C)c2)C(C)(C)C)c1C
密度	1.098 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (162.84 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 2.5 mg/mL (6.78 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7139 mL	13.5696 mL	27.1393 mL	135.6963 mL
5 mM	0.5428 mL	2.7139 mL	5.4279 mL	27.1393 mL
10 mM	0.2714 mL	1.3570 mL	2.7139 mL	13.5696 mL
20 mM	0.1357 mL	0.6785 mL	1.3570 mL	6.7848 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7139 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	1.3570 mL