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123C4

Name: 123C4
Brand: TargetMol
SKU: TP1561
Price: 1480 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.94%

货号 TP1561Cas号 2034159-30-1

123C4 是选择性的、竞争性的受体酪氨酸激酶EPHA4激动剂，Ki 为 0.65 μM.

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123C4

一键复制产品信息

很棒

纯度: 98.94%

货号 TP1561Cas号 2034159-30-1

123C4 是选择性的、竞争性的受体酪氨酸激酶EPHA4激动剂，Ki 为 0.65 μM.

规格	价格	库存
1 mg	¥ 1,480	现货
5 mg	¥ 3,320	现货
10 mg	¥ 4,870	现货
25 mg	¥ 7,670	现货
50 mg	¥ 9,870	现货
100 mg	¥ 13,900	现货
1 mL x 10 mM (in DMSO)	¥ 5,180	现货

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COA HNMR LCMS 产品操作手册

产品介绍

123C4 AI Summary

123C4 exhibits significant binding affinity to the EphA4 ligand binding domain (LBD). According to various assessments including isothermal titration calorimetry (ITC) and 2D-[13C-1H] HSQC NMR spectroscopy, it has a dissociation constant (Kd) of approximately 400.0-420.0 nM, indicating strong interaction with specific residues in the EphA4 LBD. Additionally, it has been observed to have an inhibition constant (Ki) of 640.0 nM, suggesting competitive inhibition of ligand binding. 123C4 displays high solubility up to 100000.0 nM and does not significantly bind to the EphA3 LBD. These findings imply that 123C4 may have potential bioactivity related to EphA4 receptor function and signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4 (Ki=0.65 μM)[1].
靶点活性	EphA4:0.65 μM (Ki)

化学信息

分子量	807.34
分子式	C₄₃H₄₇ClN₈O₆
CAS No.	2034159-30-1
Smiles	COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
密度	1.345 g/cm3 (Predicted)

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 252.5 mg/mL (312.76 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.19 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2386 mL	6.1932 mL	12.3864 mL	61.9318 mL
5 mM	0.2477 mL	1.2386 mL	2.4773 mL	12.3864 mL
10 mM	0.1239 mL	0.6193 mL	1.2386 mL	6.1932 mL
20 mM	0.0619 mL	0.3097 mL	0.6193 mL	3.0966 mL
50 mM	0.0248 mL	0.1239 mL	0.2477 mL	1.2386 mL
100 mM	0.0124 mL	0.0619 mL	0.1239 mL	0.6193 mL