规格

价格

库存

数量

1 mg

¥ 836

35日内发货

5 mg

¥ 1,630

35日内发货

10 mg

¥ 2,830

35日内发货

25 mg

¥ 5,880

35日内发货

生物活性

产品描述

ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.

体外活性

In vitro: ALK5 inhibitor II was identified as a cell-permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5. ALK5 inhibitor II showed less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. In addition, when cocrystallized with ALK5, ALK5 inhibitor II was found to be able to bind in the ATP site with the 1,5-naphthyridine N5 interacting with the backbone NH of His-283 [1].

化学信息

分子量	323.8
分子式	C₁₇H₁₃N₅·HCl
CAS No.	2319939-07-4
Smiles	CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1.Cl
密度	1.31g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	Ethanol: ≤0.5 mg/mL, Sonication is recommended.