Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHY34是一种晚期自噬抑制剂,具有纳摩尔水平的抑制作用。在体内,PHY34具有抗高级别浆液性卵巢癌(HGSOC)活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,230 | 现货 | ||
2 mg | ¥ 1,830 | 现货 | ||
5 mg | ¥ 2,970 | 现货 | ||
10 mg | ¥ 4,390 | 现货 | ||
25 mg | ¥ 6,910 | 现货 | ||
50 mg | ¥ 9,350 | 现货 | ||
100 mg | ¥ 12,600 | 现货 | ||
500 mg | ¥ 25,200 | 现货 |
产品描述 | PHY34 is a late stage autophagy inhibitor with nanomolar level inhibitory effect and anti-tumor activity against high-grade serous ovarian cancer (HGSOC) in vivo. |
体外活性 | In HGSOC cell lines, PHY34 showed cytotoxicity with IC50 of 4 nM. Its IC50 values in MDA-MB-435 and MDAMB-231 cell lines were 23 nM and 5.2 nM, respectively. In OVCAR3 cells, 100 nM PHY34 increased the level of early and late apoptotic cells [1]. |
体内活性 | In the hollow fiber deflector, PHY34 significantly inhibited the growth of cancer cells; In the transplanted tumor model, PHY34 reduced the ovarian tumor load. The bioavailability of mice was 56.6% after intravenous injection of 0.6 mg/kg, intraperitoneal injection of 1.8 mg/kg or oral administration of 75 mg/kg PHY34, and 2.5% after oral administration. After oral administration, the systemic clearance (CL) was 194.1 L/hr/kg, which was nearly 40 times the liver blood flow of mice, indicating that PHY34 had significant extrahepatic clearance. After oral administration, PHY34 was rapidly absorbed, and Tmax was 0.25 hr [1]. |
分子量 | 582.55 |
分子式 | C30H30O12 |
CAS No. | 2130033-55-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
DMSO:PBS (pH 7.2) (1:3): 0.25 mg/mL
DMSO: 90mg/mL (154.5mM)
Ethanol: 10 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7166 mL | 8.583 mL | 17.1659 mL | 42.9148 mL |
5 mM | 0.3433 mL | 1.7166 mL | 3.4332 mL | 8.583 mL | |
10 mM | 0.1717 mL | 0.8583 mL | 1.7166 mL | 4.2915 mL | |
20 mM | 0.0858 mL | 0.4291 mL | 0.8583 mL | 2.1457 mL | |
50 mM | 0.0343 mL | 0.1717 mL | 0.3433 mL | 0.8583 mL | |
100 mM | 0.0172 mL | 0.0858 mL | 0.1717 mL | 0.4291 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PHY34 2130033-55-3 Autophagy PHY 34 PHY-34 Inhibitor inhibitor inhibit