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Alrestatin

Name: Alrestatin
Brand: TargetMol
SKU: T5195
Price: 118 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.23%

货号 T5195Cas号 51411-04-2

别名 阿瑞司他丁, AY-22284

Alrestatin (AY-22284) 是醛糖还原酶的特异性抑制剂，能够在体外减弱大鼠血管平滑肌中葡萄糖诱导的血管紧张素 II 的产生。

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Alrestatin

一键复制产品信息

很棒

纯度: 99.23%

货号 T5195 别名 阿瑞司他丁, AY-22284Cas号 51411-04-2

Alrestatin (AY-22284) 是醛糖还原酶的特异性抑制剂，能够在体外减弱大鼠血管平滑肌中葡萄糖诱导的血管紧张素 II 的产生。

规格	价格	库存
2 mg	¥ 118	现货
5 mg	¥ 177	现货
10 mg	¥ 289	现货
25 mg	¥ 587	现货
50 mg	¥ 892	现货
100 mg	¥ 1,360	现货
200 mg	¥ 2,180	现货
1 mL x 10 mM (in DMSO)	¥ 195	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Alrestatin AI Summary

Alrestatin exhibits a broad spectrum of bioactivities, notably as an inhibitor of aldose reductase with variable potencies across different sources and experimental conditions. It shows inhibitory activity against calf lens aldose reductase, human placental aldose reductase, and rat lens aldose reductase with IC50 values ranging from 10E-5 to 34000.0 nM depending on the assay conditions. In various models, it has demonstrated the capacity to reduce sorbitol and galactitol levels in the sciatic nerve in both streptozotocinized and galactosemic rats with ED50 values between 0.000001 and 1000 mg kg-1 day-1. Additionally, it exhibits inhibitory activities against other targets such as Menin-MLL interaction, HSD17B4, Tau fibril formation, 15-hLO, RGS4, and SARS-CoV-2 with varying potencies. The compound also shows moderate liver toxicity in clinical settings, affecting 11.1% of cases, but does not present with acute or severe chronic liver conditions. This profile suggests that Alrestatin is a multifunctional bioactive agent with significant potential in targeting various biological pathways and diseases..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
别名	阿瑞司他丁, AY-22284

化学信息

分子量	255.2256
分子式	C₁₄H₉NO₄
CAS No.	51411-04-2
Smiles	OC(=O)CN1C(=O)c2cccc3cccc(C1=O)c23
密度	1.511g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (97.95 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.84 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9181 mL	19.5905 mL	39.1810 mL	195.9051 mL
5 mM	0.7836 mL	3.9181 mL	7.8362 mL	39.1810 mL
10 mM	0.3918 mL	1.9591 mL	3.9181 mL	19.5905 mL
20 mM	0.1959 mL	0.9795 mL	1.9591 mL	9.7953 mL
50 mM	0.0784 mL	0.3918 mL	0.7836 mL	3.9181 mL