UNC3866

Name: UNC3866
Brand: TargetMol
SKU: T4021
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 99.62%

货号 T4021Cas号 1872382-47-2

UNC3866 CBX7-H3 相互作用的有效拮抗剂，IC50为 66±1.2 nM。

UNC3866

一键复制产品信息

很棒

纯度: 99.62%

货号 T4021Cas号 1872382-47-2

UNC3866 CBX7-H3 相互作用的有效拮抗剂，IC50为 66±1.2 nM。

规格	价格	库存
1 mg	¥ 413	现货
5 mg	¥ 828	现货
10 mg	¥ 1,320	现货
25 mg	¥ 2,450	现货
50 mg	¥ 3,890	现货
100 mg	¥ 5,550	现货
1 mL x 10 mM (in DMSO)	¥ 1,130	现货

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COA MS LCMS 产品操作手册

产品介绍

UNC3866 AI Summary

UNC3866 exhibits binding affinity to various chromodomains, including CBX4, CBX7, CBX2, CBX6, CBX8, CDY1, CDYL1b, and CDYL2. It demonstrates selectivity towards certain chromodomains with observable selectivity ratios. The compound acts as an antagonist against CBX4, CBX7, CBX8, and CDYL2, as evidenced by IC50 values. Specific dissociation constants (Kd) for its affinity are 97.0 nM for CBX4 and CBX7, 850.0 nM for CDYL2, 910.0 nM for CDYL1b, and 6300.0 nM for CDY1. Additionally, UNC3866 shows cellular uptake with a concentration of 1.4 µM in human PC3 cells after 24 hours and has an antiproliferative activity with a GI50 value of 7600.0 nM. Bioactivity assessments using SPR and isothermal titration calorimetry have determined Kd values of 5600.0 nM and 910.0 nM for CDYL chromodomains. Moreover, UNC3866 exhibits modest antiviral activity by inhibiting SARS-CoV-2 3CL-Pro protease by 5.93% at 20 µM and reduces virus-induced cytotoxicity in VERO-6 cells by 0.19% at a concentration of 10 µM after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
靶点活性	CBX4 chromodomain:94 nM(Kd), CBX7 chromodomain:97 nM(Kd)

化学信息

分子量	795.02
分子式	C₄₃H₆₆N₆O₈
CAS No.	1872382-47-2
Smiles	CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC
密度	1.129 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 79.5 mg/mL (100 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2578 mL	6.2891 mL	12.5783 mL	62.8915 mL
5 mM	0.2516 mL	1.2578 mL	2.5157 mL	12.5783 mL
10 mM	0.1258 mL	0.6289 mL	1.2578 mL	6.2891 mL
20 mM	0.0629 mL	0.3145 mL	0.6289 mL	3.1446 mL
50 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2578 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.6289 mL