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Vulpinic Acid

Name: Vulpinic Acid
Brand: TargetMol
SKU: T3982
Price: 108 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.69%

货号 T3982Cas号 521-52-8

别名 狐衣酸, Vulpic acid, Pulvinic acid methyl ester

Vulpinic Acid (Pulvinic acid methyl ester) 是地衣代谢物，可降低人脐静脉内皮细胞 (HUVEC) 中 H2O2诱导的ROS，氧化应激和氧化应激相关损伤，可作用于厌氧菌、葡萄球菌及肠球菌。它对脉粥样硬化的研究具有潜在的价值。

为众多的药物研发团队赋能，

让新药发现更简单！

Vulpinic Acid

一键复制产品信息

很棒

纯度: 99.69%

货号 T3982 别名 狐衣酸, Vulpic acid, Pulvinic acid methyl esterCas号 521-52-8

规格	价格	库存
2 mg	¥ 108	现货
5 mg	¥ 173	现货
10 mg	¥ 298	现货
25 mg	¥ 491	现货
50 mg	¥ 713	现货
100 mg	¥ 1,070	现货
200 mg	¥ 1,580	现货
1 mL x 10 mM (in DMSO)	¥ 213	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.69%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

生物活性

产品描述	Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.
别名	狐衣酸, Vulpic acid, Pulvinic acid methyl ester

化学信息

分子量	322.31
分子式	C₁₉H₁₄O₅
CAS No.	521-52-8
Smiles	COC(=O)C(=C1\OC(=O)C(=C1O)c1ccccc1)\c1ccccc1
密度	1.375g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 60 mg/mL (186.16 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.1 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1026 mL	15.5130 mL	31.0260 mL	155.1302 mL
5 mM	0.6205 mL	3.1026 mL	6.2052 mL	31.0260 mL
10 mM	0.3103 mL	1.5513 mL	3.1026 mL	15.5130 mL
20 mM	0.1551 mL	0.7757 mL	1.5513 mL	7.7565 mL
50 mM	0.0621 mL	0.3103 mL	0.6205 mL	3.1026 mL
100 mM	0.0310 mL	0.1551 mL	0.3103 mL	1.5513 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Vulpinic Acid exhibits a broad spectrum of bioactivity. It demonstrates antimicrobial activity against Staphylococcus aureus with an IC50 value of 20.0 µg/mL and has an inhibitory effect on COX1 with an IC50 value of 218.0 µg/mL. Additionally, it inhibits 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions in BALB/c mouse mammary gland culture, with an IC50 greater than 10.0 µg/mL. In various biochemical assays, Vulpinic Acid inhibits Tau fibril formation and Thioflavin T binding with an IC50 of 223.9 nM, Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia with an IC50 of 17,740.7 nM, and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with an IC50 of 5.0 nM. It also shows limited inhibitory activity on electric eel AChE and horse BChE with inhibition rates of 4.9% and 0.35%, respectively, at 2 mg/mL. The compound affects insect development, causing imago developmental aberrations, changes in pupal weight, prolonged larval periods, and growth retardation in Spodoptera littoralis. In zebrafish larva, Vulpinic Acid exhibits hepatotoxicity at ≥ 40.0% activity and general toxicity with an MTD of 15.5 µM. It has cytotoxicity against human Huh7.5 cells with an IC50 greater than 100,000.0 nM. The antibacterial properties are shown against Staphylococcus aureus and Escherichia coli, along with inhibition of FabI enzymes in several pathogens such as Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis, and Plasmodium falciparum. Moreover, it significantly inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells (57.14%) and OATP1B3-transfected CHO cells (83.34%) at 10 µM. It exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells with IC50 values > 20,000.0 nM and > 19,952.62 nM..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl