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Dihydroberberine
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很棒纯度: 99.86%
货号 T8189Cas号 483-15-8
别名 二氢小檗碱
Dihydroberberine 可抑制人类 ether-a-go-go 相关基因 (hERG) 通道并显着降低 Hsp90 表达及其与 hERG 的相互作用，具有抗动脉粥样硬化、抗炎、降血脂和抗肿瘤活性。
其他形式的 “Dihydroberberine”:
Dihydroberberine
一键复制产品信息 很棒纯度: 99.86%
货号 T8189 别名 二氢小檗碱Cas号 483-15-8
Dihydroberberine 可抑制人类 ether-a-go-go 相关基因 (hERG) 通道并显着降低 Hsp90 表达及其与 hERG 的相互作用，具有抗动脉粥样硬化、抗炎、降血脂和抗肿瘤活性。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 315 | 现货 | |
| 5 mg | ¥ 745 | 现货 | |
| 10 mg | ¥ 1,280 | 现货 | |
| 25 mg | ¥ 2,320 | 现货 | |
| 50 mg | ¥ 3,190 | 现货 | |
| 100 mg | ¥ 4,350 | 现货 |
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产品介绍
Dihydroberberine AI Summary
Dihydroberberine shows significant bioactivity as an antimalarial agent, exhibiting potent in vitro activity against Plasmodium falciparum strains D6 and W2 with IC50 values of 0.12 µg/mL and 0.171 µg/mL, respectively. In vivo studies on Plasmodium berghei parasitized mice demonstrate an improvement in mean survival time by decreasing it by 0.2 days at a dosage of 40 mg/kg. The compound displays cytotoxicity against MRC5 cells (CC50 = 155,000 nM) and antiviral activity against HCMV in MRC5 cells (IC50 = 93,000 nM) with a selectivity index of 1.7. Additionally, Dihydroberberine demonstrates high IC50 values (>200 µg/mL) for HIV1 reverse transcriptase inhibition.
It also exhibits low aqueous solubility (<1000 µg/mL), moderate stability in acidic conditions (17%), and poor oral bioavailability (F = 2.65%). As an antidiabetic agent, it displays varying levels of activity in C57BLKS/J-db/db mice (12%-25%) but also shows toxicity, causing a reduction in liver weight and an increase in subcutaneous fat (11%-14%). The compound exhibits antiparasitic activity against Toxoplasma gondii ATCC 50839, inhibiting tachyzoite replication with an ID50 of 0.65 µM and demonstrating cytotoxicity against human fibroblasts with a TD50 of 41 µM. Furthermore, its therapeutic index is 63, indicating a potential selectivity advantage. Dihydroberberine also inhibits Sus scrofa pancreatic lipase type 2 with an IC50 of 8 µg/mL using PNPB as a substrate in a pre-incubation assay..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interaction with hERG. |
| 别名 | 二氢小檗碱 |
| 分子量 | 337.37 |
| 分子式 | C20H19NO4 |
| CAS No. | 483-15-8 |
| Smiles | COc1ccc2C=C3N(CCc4cc5OCOc5cc34)Cc2c1OC |
| 密度 | 1.37 g/cm3 at 20℃ |
| 颜色 | Yellow |
| 物理性状 | Solid |
| 存储 | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| 溶解度信息 | DMSO: 3.38 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
| 体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.96 mM), Sonication is recommended. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。 | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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