Oxendolone is a steroidal anti-androgen that acts as a pure androgen receptor antagonist, specifically binding to and blocking nuclear androgen receptors without influencing circulating testosterone or estradiol levels. In receptor assay studies, it significantly reduces nuclear androgen receptor content, with quantified data showing a marked decrease compared to untreated controls, while tissue dihydrotestosterone levels remain unaffected. This compound is commonly employed in endocrine research to dissect the role of androgen receptor signaling in prostate morphology, particularly in studies analyzing glandular atrophy and stromal tissue composition in experimental models.

Roxenone, Prostetin