规格

价格

库存

数量

5 mg

¥ 3,830

35日内发货

25 mg

¥ 16,000

35日内发货

生物活性

产品描述	SGC6870 is a novel, potent, selective, and cell-active PRMT6 inhibitor. Its mechanism of action involves binding to an allosteric site on PRMT6 rather than the catalytic active site. SGC6870 is highly potent against PRMT6 (IC₅₀ = 77 ± 6 nM) and exhibits high selectivity over other members of the PRMT family and over 30 other methyltransferases.
靶点活性 (IC₅₀)	PRMT6:77 nM
体外活性	方法：HEK293T细胞转染FLAG-PRMT6后，以SGC6870（0.04–10 μM）处理20 h，通过Western blot检测H3R2me2a和H4R3me2a水平，评估细胞内PRMT6活性抑制。结果：SGC6870呈浓度依赖性降低H3R2me2a（IC₅₀=0.9±0.1 μM）和H4R3me2a（IC₅₀=0.6±0.1 μM）水平^[1]。
别名	SGC-6870, SGC 6870

化学信息

分子量	469.39
分子式	C₂₃H₂₁BrN₂O₂S
CAS No.	2561471-27-8
Smiles	C(=O)(N1[C@@H](C=2C(NC(=O)C1)=CC=C(C)C2)C3=CC(C)=CC(C)=C3)C=4SC(Br)=CC4

储存&溶解度

存储

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 80 mg/mL (170.43 mM)

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

SGC6870