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D-Thyroxine

Name: D-Thyroxine
Brand: TargetMol
SKU: T21383
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: D-甲状腺素, Dextroxin, Dextrothyroxine;Biotirmone, Dextrothyroxine, Dextroid, Detyroxin, Dethyrona, Debetrol, Biotirmone

货号 T21383Cas号 51-49-0 一键复制产品信息纯度: 97.03%

很棒

D-Thyroxine (Dextroxin) 是一种甲状腺激素，对 TSH 的分泌具有抑制作用，可用于研究高胆固醇血症。

D-Thyroxine

一键复制产品信息

很棒

纯度: 97.03%

货号 T21383Cas号 51-49-0

别名 D-甲状腺素, Dextroxin, Dextrothyroxine;Biotirmone, Dextrothyroxine, Dextroid, Detyroxin, Dethyrona, Debetrol, Biotirmone

D-Thyroxine (Dextroxin) 是一种甲状腺激素，对 TSH 的分泌具有抑制作用，可用于研究高胆固醇血症。

规格	价格	库存
10 mg	¥ 132	现货
25 mg	¥ 190	现货
50 mg	¥ 258	现货
100 mg	¥ 365	现货
1 mL x 10 mM (in DMSO)	¥ 220	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 97.03%

颜色: 白色

性状: Solid

资源下载: COA HNMR HPLC 产品操作手册

产品介绍

D-Thyroxine AI Summary

D-Thyroxine exhibits a diverse range of biological activities, making it a potent candidate for multiple therapeutic applications. It inhibits the rat liver nuclear L-triiodothyronine receptor with an IC50 of 35.0 nM and the rat plasma membrane L-triiodothyronine receptor with an IC50 of 2500.0 nM in vitro. Additionally, it displaces [3H]L-689560 from the NMDA receptor glycine site in rat brain membranes with an IC50 of 330.0 nM. D-Thyroxine also inhibits transthyretin amyloidosis by preventing fibril formation and demonstrates moderate activity in stabilizing urea-induced transthyretin dissociation. It exerts various bioactivities, including modulation of Lamin A splicing (potency of 89.1 nM), inhibition of HSD17B4 (IC50 of 12589.3 nM), interaction inhibition between thyroid hormone receptor and steroid receptor coregulator 2 (potency of 5.6 nM), and competition for the Menin-MLL interaction in MLL related leukemias (potency of 12589.3 nM). The compound also inhibits Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia (IC50 of 19905.4 nM), HADH2 (potency of 15848.9 nM), and affects enzymes such as Cytochrome P450 2C9 (IC50 of 6309.6 nM) and Cytochrome P450 1A2 (potency of 15848.93 nM). It blocks the interaction between CBF-beta and RUNX1 for treating Acute Myeloid Leukemia (potency of 11220.2 nM) and inhibits Marburg Virus entry into cells (potency of 22296.9 nM). D-Thyroxine also inhibits the uptake of 3,3',5-triiodothyronine and thyroxine in Xenopus laevis oocytes, with inhibition activities of 21.0% and 76.0%, respectively. It also inhibits the uptake of L-T4 in Oatp14-expressing HEK293 cells with a Ki value of 270.0 nM. In terms of toxicity, it exhibits moderate liver toxicity with hepatotoxicity observed in 40.2% of cases based on clinical trial data, but no acute liver toxicity or other severe liver conditions such as cytolytic hepatitis, cirrhosis, or liver tumors were noted. The compound shows binding affinity and activity in various in vitro assays targeting a wide array of receptors and enzymes. These include a range of receptors such as HRH2, DRD1, ADRB1, ADRB2, ADRB3, OPRK1, CHRNA4, HTR2C, ADRA1A, SLC6A3, HRH1, HTR1A, HTR2A, and CNR1. It functions as both an agonist and antagonist at receptors like DRD1, CHRM2, HTR1A, ADRA1A, ADRA2A, HTR2A, HTR2B, and CNR1 in in vitro cell-based assays, and it inhibits certain enzymes including PDE4D and MAOA. This broad spectrum of interactions suggests significant pharmaceutical potential that could be explored further..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	D-Thyroxine (Dextroxin) could lower cholesterol and also increases hepatic lipase which in turn improves utilization of triglycerides, leading to improve apolipoprotein E cholesterol particles.
别名	D-甲状腺素, Dextroxin, Dextrothyroxine;Biotirmone, Dextrothyroxine, Dextroid, Detyroxin, Dethyrona, Debetrol, Biotirmone

化学信息

分子量	776.87
分子式	C₁₅H₁₁I₄NO₄
CAS No.	51-49-0
Smiles	O(C1=CC(I)=C(O)C(I)=C1)C2=C(I)C=C(C[C@H](C(O)=O)N)C=C2I
密度	2.4440 g/cm3 (Estimated)

储存&溶解度

存储

溶解度信息

H2O: Insoluble

DMSO: 55 mg/mL (70.8 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.57 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2872 mL	6.4361 mL	12.8722 mL	64.3608 mL
5 mM	0.2574 mL	1.2872 mL	2.5744 mL	12.8722 mL
10 mM	0.1287 mL	0.6436 mL	1.2872 mL	6.4361 mL
20 mM	0.0644 mL	0.3218 mL	0.6436 mL	3.2180 mL
50 mM	0.0257 mL	0.1287 mL	0.2574 mL	1.2872 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

TSH Inhibitor inhibit hypercholesterolemia Endogenous Metabolite D-Thyroxine DThyroxine D-T4 D Thyroxine

D-Thyroxine

D-Thyroxine

D-Thyroxine 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词