ALDH1A3-IN-1 (Compound 14) (0-200 μM, 96 h) shows antiproliferative activity in prostate cancer cell lines [1]. ALDH1A3-IN-1 (0-200 μM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner [1]. Cell Proliferation Assay [1] Cell Line: PC3, LNCaP, and DU145 cells Concentration: 12.5-200 μM Incubation Time: 96 h Result: Showed antiproliferative activity with IC 50 values of 47 ± 6, 25 ± 1, and 61 ± 5 μM against PC3, LNCaP, and DU145 cells. Cell Viability Assay [1] Cell Line: Primary cells cultured at early passage from human prostate tissue biopsies Concentration: 50 and 200 μM Incubation Time: 72 h Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures.