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Aldometanib

Aldometanib

产品编号 T60122   CAS 2904601-67-6
别名: Compound IA-47 (Br- base 2246625-81-8)

Aldometanib (LXY-05-029) 是一种具有口服活性的醛缩酶抑制剂,可以阻止FBP 与v-ATPase 相关的醛缩酶结合,并激活溶酶体 AMPK 。Aldometanib 可用于代谢稳态的研究。

TargetMol的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
Aldometanib Chemical Structure
Aldometanib, CAS 2904601-67-6
规格 价格/CNY 货期 数量
1 mg ¥ 336 现货
5 mg ¥ 756 现货
10 mg ¥ 1,212 现货
25 mg ¥ 2,319 现货
50 mg ¥ 3,671 现货
1 mL * 10 mM (in DMSO) ¥ 997 现货
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
PMA限时半价
产品目录号及名称: Aldometanib (T60122)
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参考文献
产品描述 Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib prevents FBP from binding to v-ATPase-associated aldolase and activates lysosomal AMPK. Aldometanib can be used for the research of metabolic homeostasis [1].
体外活性 Aldometanib (0-1000 nM; 2 h) activates AMPK through preventing aldolase from binding to FBP to engender a pseudo-starvation signal [1]. Western Blot Analysis [1] Cell Line: Mouse primary hepatocytes, MEFs cells Concentration: 0-1000 nM Incubation Time: 2 h Result: Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells. Immunofluorescence [1] Cell Line: MEFs cells Concentration: 5 nM Incubation Time: 2 h Result: Inhibited TRPVs and induces AXIN lysosomal translocation.
体内活性 Aldometanib (oral; 0-10 mpk) lowers blood glucose in lean mice [1]. Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose and alleviates fatty liver in obese hyperglycaemic mice [1]. Aldometanib alleviates fatty liver and nonalcoholic steatohepatitis [1]. Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice [1]. Aldometanib (oral; 0-50 μM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway [1]. Animal Model: Lean mice [1] Dosage: 0-10 mpk Administration: Oral Result: Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake. Animal Model: Obese hyperglycaemic mice [1] Dosage: 2-10 mpk Administration: Oral, twice daily, for a week Result: Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass. Animal Model: NASH mice [1] Dosage: 2 mpk Administration: Oral, twice-daily, for a month Result: Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice. Animal Model: C. elegans [1] Dosage: 0-50 μM Administration: Oral, 0-50 days Result: Promoted oxidative stress resistance and mitochondrial functions in C. elegans. Animal Model: C57BL/6 mice [1] Dosage: 100 μg/mL Administration: Oral Result: Extended lifespan, elevated NAD + levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.
别名 Compound IA-47 (Br- base 2246625-81-8)
分子量 593.46
分子式 C27H43Cl2IN2
CAS No. 2904601-67-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 60 mg/mL (101.1 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.685 mL 8.4252 mL 16.8503 mL 42.1258 mL
5 mM 0.337 mL 1.685 mL 3.3701 mL 8.4252 mL
10 mM 0.1685 mL 0.8425 mL 1.685 mL 4.2126 mL
20 mM 0.0843 mL 0.4213 mL 0.8425 mL 2.1063 mL
50 mM 0.0337 mL 0.1685 mL 0.337 mL 0.8425 mL
100 mM 0.0169 mL 0.0843 mL 0.1685 mL 0.4213 mL

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TargetMol Library Books参考文献

1. Zhang CS, et al. The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab. 2022 Oct;4(10):1369-1401.
Ginkgolide C Brazilin Hernandezine Methyl cinnamate AMPK activator 12 AMPK activator 4 MRT67307 HCl (1190378-57-4(free base)) EB-3D

相关化合物库

该产品包含在如下化合物库中:
抑制剂库 激酶抑制剂库 抗代谢疾病化合物库 抗氧化化合物库 线粒体靶向库 表观遗传库 抗卵巢癌化合物库 抗癌化合物库 抗肥胖化合物库 神经元分化化合物库

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Keywords

Aldometanib 2904601-67-6 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK CompoundIA47 Compound IA-47 (Br- base 2246625-81-8) Br- base 2246625-81-8 Compound IA-47 Inhibitor inhibitor inhibit

 

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