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Midodrine
Synonyms: 米多君, (±)-Midodrin货号 T22369Cas号 42794-76-3 一键复制产品信息纯度: 99.89%
很棒
很棒Midodrine ((±)-Midodrin) 是α1受体激动剂，用于研究家族性自主神经异常以及直立性低血压。
Midodrine
一键复制产品信息 很棒纯度: 99.89%
货号 T22369Cas号 42794-76-3
别名 米多君, (±)-Midodrin
Midodrine ((±)-Midodrin) 是α1受体激动剂，用于研究家族性自主神经异常以及直立性低血压。
其他形式的 “Midodrine”:
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 185 | 现货 | |
| 2 mg | ¥ 258 | 现货 | |
| 5 mg | ¥ 413 | 现货 | |
| 10 mg | ¥ 663 | 现货 | |
| 25 mg | ¥ 1,080 | 现货 | |
| 50 mg | ¥ 1,630 | 现货 | |
| 100 mg | ¥ 2,430 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 397 | 现货 |
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产品介绍
Midodrine AI Summary
Midodrine shows relevant bioactivities related to liver enzyme activity, affecting markers such as alkaline phosphatase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, lactate dehydrogenase, and gamma-glutamyl transferase, albeit with varying degrees of effect. Importantly, it demonstrates no liver toxicity or hepatic side effects, with all hepatic side effect scores—including bilirubinemia, cholecystitis, cirrhosis, hepatitis, and jaundice—recorded as 0.0 according to the Drug Induced Liver Injury Prediction System (DILIps). Pharmacokinetically, Midodrine has a pKa value of 7.59, a LogD7.4 of -0.71 indicating it is hydrophilic, and an intrinsic clearance of less than 3.0 uL.min-1.(10^6cells)-1 in human hepatocytes.
In antiviral testing, Midodrine exhibits activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells, with a hit score of 0.1739 implying moderate efficacy, and an IC50 value greater than 20,000.0 nM in VERO-6 cells, indicating low potency in inhibiting virus-induced cytotoxicity. Additionally, it shows inhibitory activity against the human HDAC6 enzyme, with inhibition rates of 12.02% using a commercial peptide substrate and 16.07% using a custom peptide substrate, suggesting some potential as an HDAC6 inhibitor.
Despite extensive testing against various receptors and enzymes, Midodrine generally displayed limited bioactivity, with AC50 values exceeding 10000.0 nM across most targets, indicating weak or insignificant pharmacological effects on the evaluated receptors and enzymes..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | Midodrine ((±)-Midodrin), an adrenergic alpha-1 agonist, belongs to the class of medications known as vasopressors. |
| 别名 | 米多君, (±)-Midodrin |
| 分子量 | 254.28 |
| 分子式 | C12H18N2O4 |
| CAS No. | 42794-76-3 |
| Smiles | C(CNC(CN)=O)(O)C1=C(OC)C=CC(OC)=C1 |
| 密度 | 1.204 g/cm3 (Predicted) |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准 | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 50 mg/mL (196.63 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。 | ||||||||||||||||||||||||||||||||||||
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
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