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Catalpol

Name: Catalpol
Brand: TargetMol
SKU: T2780
Price: 190 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.89%

货号 T2780Cas号 2415-24-9

别名 梓醇, Digitalis purpurea L, Catalpinoside

Catalpol (Catalpinoside) 是一种在Rehmannia glutinosa 中发现的鸢尾花苷，具有神经保护、降血糖、抗癌、抗痉挛、抗氧化、抗HBV 和抗肝炎病毒作用。

Catalpol

一键复制产品信息

很棒

纯度: 99.89%

货号 T2780 别名 梓醇, Digitalis purpurea L, CatalpinosideCas号 2415-24-9

Catalpol (Catalpinoside) 是一种在Rehmannia glutinosa 中发现的鸢尾花苷，具有神经保护、降血糖、抗癌、抗痉挛、抗氧化、抗HBV 和抗肝炎病毒作用。

规格	价格	库存	数量
20 mg	¥ 190	现货
1 mL x 10 mM (in DMSO)	¥ 210	现货

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大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.89%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Catalpol AI Summary

Catalpol exhibits a range of biological activities. It demonstrates antiproliferative effects against various human cell lines, including A2780, HBL100, HeLa, SW1573, T47D, and WiDr, with a GI50 value exceeding 100,000.0 nM for all tested lines based on the SRB assay results, suggesting limited cytotoxic effects at these concentrations. Additionally, it displays significant antihyperglycemic effects in streptozotocin-induced diabetic Wistar rats by reducing plasma glucose levels, with reductions of 24.33% at 0.1 mg/kg dosage and 8.53% at 0.01 mg/kg dosage. In terms of insecticidal activity, Catalpol is effective against Tribolium castaneum larvae, showing a pupal stage duration of 8.2 days and a mortality rate of 73.3% at 60 ug/uL. It also exhibits antifeedant activities such as a relative growth rate of -0.01 mg/mg/day and a relative consumption rate of 0.017 mg/mg/day at 200 ug/disk, along with an efficiency of conversion of ingested food of -66.1%. Catalpol inhibits Thermus aquaticus-DNA polymerase with an IC50 of 47800.0 nM and shows activity in a qHTS assay for GCN5L2 inhibitors with a potency of 39810.7 nM. It possesses estrogenic activity in human MVLN cells, with activity levels of 54.03% at 100 ug/mL and 75.78% at 20 ug/mL compared to estradiol. The compound shows moderate inhibitory activity against COX1 (44.2%-63.7%) and weak inhibitory action against COX2 (less than 30%). Additionally, Catalpol exhibits hepatoprotective activity against APAP-induced toxicity in human HepG2 cells, resulting in a 69.1% cell survival rate, and demonstrates inhibition of LPS-induced NO production in mouse BV2 cells with an IC50 of 7300.0 nM. It also shows cytotoxicity against mouse BV2 cells (86.1% activity) and various human cell lines (e.g., A2780, BGC823, HT-29, A549, and Bel7402) with IC50 values greater than 10,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Catalpol (Catalpinoside) is an iridoid glycoside with neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.
别名	梓醇, Digitalis purpurea L, Catalpinoside

化学信息

分子量	362.33
分子式	C₁₅H₂₂O₁₀
CAS No.	2415-24-9
Smiles	OCC1OC(OC2OC=CC3C(O)C4OC4(CO)C23)C(O)C(O)C1O
密度	1.72 g/cm3

储存&溶解度

存储

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 252.5 mg/mL (696.88 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7599 mL	13.7996 mL	27.5991 mL	137.9957 mL
5 mM	0.5520 mL	2.7599 mL	5.5198 mL	27.5991 mL
10 mM	0.2760 mL	1.3800 mL	2.7599 mL	13.7996 mL
20 mM	0.1380 mL	0.6900 mL	1.3800 mL	6.8998 mL
50 mM	0.0552 mL	0.2760 mL	0.5520 mL	2.7599 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3800 mL

TCMIP相关数据

中药材来源及性味归经

中药材名称	中药材拉丁名	性	味	归经
十万错	Asystasia nemorum Nees	凉	淡	心, 肝

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

virus neuroprotective iridoid Inhibitor inhibit hypoglycemic Hepatitis B virus hepatitis HBV glycoside diuretic Catalpol anti-inflammatory anti-cancer

Catalpol

Catalpol

Catalpol 相关产品

产品介绍

TCMIP相关数据

计算器

体内实验配液计算器

剂量转换

引用文献

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