Name: 2-Deoxy-D-glucose
Brand: TargetMol
SKU: T6742
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

100 mg

¥ 153

现货

500 mg

¥ 326

现货

1 g

¥ 413

现货

5 g

¥ 987

现货

10 g

¥ 1,490

现货

1 mL x 10 mM (in DMSO)

¥ 355

现货

产品介绍

生物活性

产品描述	2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
靶点活性	B-CPAP cells viability:1.154 mM, Caenorhabditis elegans growth:19.5 mM, THP-1 cells viability:16.14 mM, HL-60 cells viability:15.55 mM, Kasumi-1 cells viability:0.92 mM, NB4 cells viability:5.75 mM, EtHK enzyme:5.66 mM (Km)
体外活性	方法：胰腺癌细胞 MIA PaCa2、BxPC-3、ASPC-1 和卵巢癌细胞 OVCAR-3、HEY、SK-OV-3 用 2-Deoxy-D-glucose (0.01-100 mM) 处理 48 h，使用 MTT 检测细胞增殖。结果：2-Deoxy-D-glucose 对肿瘤细胞显示出显著的抗增殖活性，IC50 值在 1.45-13.34 mM 之间。[1] 方法：三阴性乳腺癌细胞 Hs578T 用 2-Deoxy-D-glucose (15 mM) 处理 24 天，使用 Migration assay 和 Invasion assay 检测细胞运动情况。结果：2-Deoxy-D-glucose 抑制 Hs578T 细胞的迁移、侵袭。[2]
体内活性	方法：为研究对白细胞亚群分布和功能的影响，将 2-Deoxy-D-glucose (500-1500 mg/kg) 腹腔注射 BDF1 小鼠，注射一次或三次。结果：一次注射高达 1500 mg/kg 的 2-Deoxy-D-glucose 的小鼠的血糖浓度呈剂量依赖性增加。在一次或三次注射高达 1500 mg/kg 的 2-Deoxy-D-glucose 后，皮质酮水平、脾脏中的白细胞计数和胸腺中的 CD3+ 细胞增加。2-Deoxy-D-glucose 给药诱导胸腺和脾细胞分布和功能的剂量依赖性变化。[3] 方法：为检测体内抗肿瘤活性，将 2-Deoxy-D-glucose (1000 mg/kg) 腹腔注射给携带黑色素瘤 B16 的 C57BL/6 小鼠，每天一次，持续八天。结果：2-Deoxy-D-glucose 显著抑制肿瘤生长。TAMs 在 2-Deoxy-D-glucose 处理后显示Arg、Fizz、CD206 和 Vegf 表达显著降低。[4]
细胞实验	2×103 H460 or H157 cells are seeded in 96-well cell culture plates. Cells are treated with 5 mM 2-DG only, 5 or 10 μM IGF1R inhibitor II only, or a combination of 2-DG and IGF1R inhibitor II. Cell growth inhibition is determined after 48 h by the CellTiter 96® AQueous nonradioactive cell proliferation assay. (Only for Reference)
别名	NSC 15193, D-Arabino-2-deoxyhexose, D-2-脱氧葡萄糖, Ba 2758, 2-脱氧-D-葡萄糖, 2-DG, 2-deoxyglucose, 2-Deoxy-D-arabino-hexose

化学信息

分子量	164.16
分子式	C₆H₁₂O₅
CAS No.	154-17-6
Smiles	OC[C@H]1OC(O)C[C@@H](O)[C@@H]1O
密度	1.533 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature,store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 100 mg/mL (609.16 mM), Sonication is recommended.

DMSO: 60 mg/mL (365.5 mM), Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	304.5809 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	60.9162 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	30.4581 mL
20 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2290 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	6.0916 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	3.0458 mL

体内实验配液计算器