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Monastrol

Name: Monastrol
Brand: TargetMol
SKU: T4048
Price: 263 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: (±)-Monastrol

货号 T4048Cas号 329689-23-8 一键复制产品信息纯度: 98.59%

很棒

Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂，IC50值为 14 μM。

Monastrol

一键复制产品信息

很棒

纯度: 98.59%

货号 T4048Cas号 329689-23-8

别名 (±)-Monastrol

Monastrol ((±)-Monastrol) 是一种具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂，IC50值为 14 μM。

规格	价格	库存
1 mg	¥ 263	现货
5 mg	¥ 662	现货
10 mg	¥ 892	现货
25 mg	¥ 1,650	现货
50 mg	¥ 2,650	现货
100 mg	¥ 3,970	现货
200 mg	¥ 5,790	现货
1 mL x 10 mM (in DMSO)	¥ 643	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 98.59%

颜色: 白色至黄色

性状: Solid

资源下载: COA LCMS HNMR 产品操作手册

产品介绍

Monastrol AI Summary

Monastrol exhibits a broad spectrum of bioactivities, prominently including inhibition of Eg5 ATPase activity with varied IC50 values across different systems, showing an IC50 of 6100 nM in HeLa cells and E. coli, and 5470 nM against human full-length Eg5 ATPase activity. It also induces monoastral spindles in HeLa cells, induces mitotic arrest in HCT116 cells (EC50 of 1200 nM for DNA content doubling and 1500 nM for increased phospho-histone H3 levels), and causes cell cycle arrest in HeLa cells at 100 µM concentration. The compound exhibits antiproliferative activity against numerous human cell lines, showing high potency against HCT116 and hTERT-HME1 cells. It demonstrates variable cytotoxicity with IC50 values of 59100 nM in MCF7 cells, 176900 nM in HeLa cells, and notably lower cytotoxic activity in other lines. Additionally, Monastrol inhibits multiple enzymes including Cytochrome P450 variants, Aldehyde Dehydrogenase 1, and Polymerase Kappa, and exhibits growth inhibition against human tumor cell lines with GI50 values ranging up to 100 µM. The compound also shows vasodilating activity in rat aortic rings and inhibits Plasmodium falciparum proliferation. Specific bioactivities include induction of apoptosis in cancer cell lines, inhibition of kinesin activity, and modulation of GABAA receptors. Notably, the compound has lower activity against certain targets, such as human HDAC6, where it exhibits minimal inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
靶点活性	KIF11(Eg5):14 μM
别名	(±)-Monastrol

化学信息

分子量	292.35
分子式	C₁₄H₁₆N₂O₃S
CAS No.	329689-23-8
Smiles	CCOC(=O)C1=C(C)NC(=S)NC1c1cccc(O)c1
密度	1.34 g/cm3 at 20℃

储存&溶解度

存储

溶解度信息

DMSO: 55 mg/mL (188.13 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.84 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4206 mL	17.1028 mL	34.2056 mL	171.0279 mL
5 mM	0.6841 mL	3.4206 mL	6.8411 mL	34.2056 mL
10 mM	0.3421 mL	1.7103 mL	3.4206 mL	17.1028 mL
20 mM	0.1710 mL	0.8551 mL	1.7103 mL	8.5514 mL
50 mM	0.0684 mL	0.3421 mL	0.6841 mL	3.4206 mL
100 mM	0.0342 mL	0.1710 mL	0.3421 mL	1.7103 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。